Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their alterations in explanted human diseased hearts.
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Nature Portfolio
2020
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oai:doaj.org-article:f630452532e74b488261b252cd5af0832021-12-02T17:33:14ZImpaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node10.1038/s41467-019-14039-82041-1723https://doaj.org/article/f630452532e74b488261b252cd5af0832020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14039-8https://doaj.org/toc/2041-1723The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their alterations in explanted human diseased hearts.Ning LiAnuradha KalyanasundaramBrian J. HansenEsthela J. ArtigaRoshan SharmaSuhaib H. AbudulwahedKatelynn M. HelfrichGalina RozenbergPei-Jung WuStanislav ZakharkinSandor GyorkePaul ML. JanssenBryan A. WhitsonNahush A. MokadamBrandon J. BiesiadeckiFederica AccorneroJohn D. HummelPeter J. MohlerHalina DobrzynskiJichao ZhaoVadim V. FedorovNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ning Li Anuradha Kalyanasundaram Brian J. Hansen Esthela J. Artiga Roshan Sharma Suhaib H. Abudulwahed Katelynn M. Helfrich Galina Rozenberg Pei-Jung Wu Stanislav Zakharkin Sandor Gyorke Paul ML. Janssen Bryan A. Whitson Nahush A. Mokadam Brandon J. Biesiadecki Federica Accornero John D. Hummel Peter J. Mohler Halina Dobrzynski Jichao Zhao Vadim V. Fedorov Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node |
| description |
The role of of voltage-gated sodium channels (Nav) in pacemaking and conduction of the human sinoatrial node is unclear. Here, the authors investigate existence and function of neuronal and cardiac Nav in human sinoatrial nodes, and demonstrate their alterations in explanted human diseased hearts. |
| format |
article |
| author |
Ning Li Anuradha Kalyanasundaram Brian J. Hansen Esthela J. Artiga Roshan Sharma Suhaib H. Abudulwahed Katelynn M. Helfrich Galina Rozenberg Pei-Jung Wu Stanislav Zakharkin Sandor Gyorke Paul ML. Janssen Bryan A. Whitson Nahush A. Mokadam Brandon J. Biesiadecki Federica Accornero John D. Hummel Peter J. Mohler Halina Dobrzynski Jichao Zhao Vadim V. Fedorov |
| author_facet |
Ning Li Anuradha Kalyanasundaram Brian J. Hansen Esthela J. Artiga Roshan Sharma Suhaib H. Abudulwahed Katelynn M. Helfrich Galina Rozenberg Pei-Jung Wu Stanislav Zakharkin Sandor Gyorke Paul ML. Janssen Bryan A. Whitson Nahush A. Mokadam Brandon J. Biesiadecki Federica Accornero John D. Hummel Peter J. Mohler Halina Dobrzynski Jichao Zhao Vadim V. Fedorov |
| author_sort |
Ning Li |
| title |
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node |
| title_short |
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node |
| title_full |
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node |
| title_fullStr |
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node |
| title_full_unstemmed |
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node |
| title_sort |
impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/f630452532e74b488261b252cd5af083 |
| work_keys_str_mv |
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| _version_ |
1718380037156110336 |