Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses

Abstract Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself. The dynamic regulation of mammalian cell signaling pathways is often modulated by cascades of protein post-translational modif...

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Autores principales:	Flurina Boehi, Patrick Manetsch, Michael O. Hottiger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/f63289d7a03940f38aab071102d8ad1d
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spelling	oai:doaj.org-article:f63289d7a03940f38aab071102d8ad1d2021-11-08T11:14:36ZInterplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses10.1038/s41421-021-00323-92056-5968https://doaj.org/article/f63289d7a03940f38aab071102d8ad1d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41421-021-00323-9https://doaj.org/toc/2056-5968Abstract Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself. The dynamic regulation of mammalian cell signaling pathways is often modulated by cascades of protein post-translational modifications (PTMs). ADP-ribosylation is a PTM that is catalyzed by ADP-ribosyltransferases and manifests as mono- (MARylation) or poly- (PARylation) ADP-ribosylation depending on the addition of one or multiple ADP-ribose units to protein substrates. ADP-ribosylation has recently emerged as an important cell regulator that impacts a plethora of cellular processes, including many intracellular signaling events. Here, we provide an overview of the interplay between the intracellular diphtheria toxin-like ADP-ribosyltransferase (ARTD) family members and five selected signaling pathways (including NF-κB, JAK/STAT, Wnt-β-catenin, MAPK, PI3K/AKT), which are frequently described to control or to be controlled by ADP-ribosyltransferases and how these interactions impact the cellular responses.Flurina BoehiPatrick ManetschMichael O. HottigerNature Publishing GrouparticleCytologyQH573-671ENCell Discovery, Vol 7, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Flurina Boehi Patrick Manetsch Michael O. Hottiger Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
description	Abstract Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself. The dynamic regulation of mammalian cell signaling pathways is often modulated by cascades of protein post-translational modifications (PTMs). ADP-ribosylation is a PTM that is catalyzed by ADP-ribosyltransferases and manifests as mono- (MARylation) or poly- (PARylation) ADP-ribosylation depending on the addition of one or multiple ADP-ribose units to protein substrates. ADP-ribosylation has recently emerged as an important cell regulator that impacts a plethora of cellular processes, including many intracellular signaling events. Here, we provide an overview of the interplay between the intracellular diphtheria toxin-like ADP-ribosyltransferase (ARTD) family members and five selected signaling pathways (including NF-κB, JAK/STAT, Wnt-β-catenin, MAPK, PI3K/AKT), which are frequently described to control or to be controlled by ADP-ribosyltransferases and how these interactions impact the cellular responses.
format	article
author	Flurina Boehi Patrick Manetsch Michael O. Hottiger
author_facet	Flurina Boehi Patrick Manetsch Michael O. Hottiger
author_sort	Flurina Boehi
title	Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
title_short	Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
title_full	Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
title_fullStr	Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
title_full_unstemmed	Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
title_sort	interplay between adp-ribosyltransferases and essential cell signaling pathways controls cellular responses
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/f63289d7a03940f38aab071102d8ad1d
work_keys_str_mv	AT flurinaboehi interplaybetweenadpribosyltransferasesandessentialcellsignalingpathwayscontrolscellularresponses AT patrickmanetsch interplaybetweenadpribosyltransferasesandessentialcellsignalingpathwayscontrolscellularresponses AT michaelohottiger interplaybetweenadpribosyltransferasesandessentialcellsignalingpathwayscontrolscellularresponses
_version_	1718442391351853056

Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses

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