SOX9 duplication linked to intersex in deer.

A complex network of genes determines sex in mammals. Here, we studied a European roe deer with an intersex phenotype that was consistent with a XY genotype with incomplete male-determination. Whole genome sequencing and quantitative real-time PCR analyses revealed a triple dose of the SOX9 gene, al...

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Autores principales:	Regina Kropatsch, Gabriele Dekomien, Denis A Akkad, Wanda M Gerding, Elisabeth Petrasch-Parwez, Neil D Young, Janine Altmüller, Peter Nürnberg, Robin B Gasser, Jörg T Epplen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6330580c9cc4b2c9aedecf410ced5c3
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spelling	oai:doaj.org-article:f6330580c9cc4b2c9aedecf410ced5c32021-11-18T08:56:30ZSOX9 duplication linked to intersex in deer.1932-620310.1371/journal.pone.0073734https://doaj.org/article/f6330580c9cc4b2c9aedecf410ced5c32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040047/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A complex network of genes determines sex in mammals. Here, we studied a European roe deer with an intersex phenotype that was consistent with a XY genotype with incomplete male-determination. Whole genome sequencing and quantitative real-time PCR analyses revealed a triple dose of the SOX9 gene, allowing insights into a new genetic defect in a wild animal.Regina KropatschGabriele DekomienDenis A AkkadWanda M GerdingElisabeth Petrasch-ParwezNeil D YoungJanine AltmüllerPeter NürnbergRobin B GasserJörg T EpplenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73734 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Regina Kropatsch Gabriele Dekomien Denis A Akkad Wanda M Gerding Elisabeth Petrasch-Parwez Neil D Young Janine Altmüller Peter Nürnberg Robin B Gasser Jörg T Epplen SOX9 duplication linked to intersex in deer.
description	A complex network of genes determines sex in mammals. Here, we studied a European roe deer with an intersex phenotype that was consistent with a XY genotype with incomplete male-determination. Whole genome sequencing and quantitative real-time PCR analyses revealed a triple dose of the SOX9 gene, allowing insights into a new genetic defect in a wild animal.
format	article
author	Regina Kropatsch Gabriele Dekomien Denis A Akkad Wanda M Gerding Elisabeth Petrasch-Parwez Neil D Young Janine Altmüller Peter Nürnberg Robin B Gasser Jörg T Epplen
author_facet	Regina Kropatsch Gabriele Dekomien Denis A Akkad Wanda M Gerding Elisabeth Petrasch-Parwez Neil D Young Janine Altmüller Peter Nürnberg Robin B Gasser Jörg T Epplen
author_sort	Regina Kropatsch
title	SOX9 duplication linked to intersex in deer.
title_short	SOX9 duplication linked to intersex in deer.
title_full	SOX9 duplication linked to intersex in deer.
title_fullStr	SOX9 duplication linked to intersex in deer.
title_full_unstemmed	SOX9 duplication linked to intersex in deer.
title_sort	sox9 duplication linked to intersex in deer.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f6330580c9cc4b2c9aedecf410ced5c3
work_keys_str_mv	AT reginakropatsch sox9duplicationlinkedtointersexindeer AT gabrieledekomien sox9duplicationlinkedtointersexindeer AT denisaakkad sox9duplicationlinkedtointersexindeer AT wandamgerding sox9duplicationlinkedtointersexindeer AT elisabethpetraschparwez sox9duplicationlinkedtointersexindeer AT neildyoung sox9duplicationlinkedtointersexindeer AT janinealtmuller sox9duplicationlinkedtointersexindeer AT peternurnberg sox9duplicationlinkedtointersexindeer AT robinbgasser sox9duplicationlinkedtointersexindeer AT jorgtepplen sox9duplicationlinkedtointersexindeer
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SOX9 duplication linked to intersex in deer.

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