Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

Endocytosis of the type I interferon receptor (IFNAR) is required for JAK/STAT signalling. Here the authors show that the internalized IFNAR1 and IFNAR2 subunits are differentially sorted by the retromer complex at the early endosome and this controls JAK/STAT signalling and gene transcription.

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Autores principales:	Daniela Chmiest, Nanaocha Sharma, Natacha Zanin, Christine Viaris de Lesegno, Massiullah Shafaq-Zadah, Vonick Sibut, Florent Dingli, Philippe Hupé, Stephan Wilmes, Jacob Piehler, Damarys Loew, Ludger Johannes, Gideon Schreiber, Christophe Lamaze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f636bcea828644879cdbcf4b1bac6f94
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spelling	oai:doaj.org-article:f636bcea828644879cdbcf4b1bac6f942021-12-02T17:32:35ZSpatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex10.1038/ncomms134762041-1723https://doaj.org/article/f636bcea828644879cdbcf4b1bac6f942016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13476https://doaj.org/toc/2041-1723Endocytosis of the type I interferon receptor (IFNAR) is required for JAK/STAT signalling. Here the authors show that the internalized IFNAR1 and IFNAR2 subunits are differentially sorted by the retromer complex at the early endosome and this controls JAK/STAT signalling and gene transcription.Daniela ChmiestNanaocha SharmaNatacha ZaninChristine Viaris de LesegnoMassiullah Shafaq-ZadahVonick SibutFlorent DingliPhilippe HupéStephan WilmesJacob PiehlerDamarys LoewLudger JohannesGideon SchreiberChristophe LamazeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Chmiest Nanaocha Sharma Natacha Zanin Christine Viaris de Lesegno Massiullah Shafaq-Zadah Vonick Sibut Florent Dingli Philippe Hupé Stephan Wilmes Jacob Piehler Damarys Loew Ludger Johannes Gideon Schreiber Christophe Lamaze Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
description	Endocytosis of the type I interferon receptor (IFNAR) is required for JAK/STAT signalling. Here the authors show that the internalized IFNAR1 and IFNAR2 subunits are differentially sorted by the retromer complex at the early endosome and this controls JAK/STAT signalling and gene transcription.
format	article
author	Daniela Chmiest Nanaocha Sharma Natacha Zanin Christine Viaris de Lesegno Massiullah Shafaq-Zadah Vonick Sibut Florent Dingli Philippe Hupé Stephan Wilmes Jacob Piehler Damarys Loew Ludger Johannes Gideon Schreiber Christophe Lamaze
author_facet	Daniela Chmiest Nanaocha Sharma Natacha Zanin Christine Viaris de Lesegno Massiullah Shafaq-Zadah Vonick Sibut Florent Dingli Philippe Hupé Stephan Wilmes Jacob Piehler Damarys Loew Ludger Johannes Gideon Schreiber Christophe Lamaze
author_sort	Daniela Chmiest
title	Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
title_short	Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
title_full	Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
title_fullStr	Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
title_full_unstemmed	Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
title_sort	spatiotemporal control of interferon-induced jak/stat signalling and gene transcription by the retromer complex
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f636bcea828644879cdbcf4b1bac6f94
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Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

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