Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

Endocytosis of the type I interferon receptor (IFNAR) is required for JAK/STAT signalling. Here the authors show that the internalized IFNAR1 and IFNAR2 subunits are differentially sorted by the retromer complex at the early endosome and this controls JAK/STAT signalling and gene transcription.

Saved in:
Bibliographic Details
Main Authors: Daniela Chmiest, Nanaocha Sharma, Natacha Zanin, Christine Viaris de Lesegno, Massiullah Shafaq-Zadah, Vonick Sibut, Florent Dingli, Philippe Hupé, Stephan Wilmes, Jacob Piehler, Damarys Loew, Ludger Johannes, Gideon Schreiber, Christophe Lamaze
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/f636bcea828644879cdbcf4b1bac6f94
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/f636bcea828644879cdbcf4b1bac6f94

Similar Items