Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review

Abstract Objectives Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systema...

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Autores principales:	Jonathan Willis, Siwei Li, St John Crean, Fadi N. Barrak
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cytotoxicity implant peri‐implantitis Ti‐6Al‐4 V alloy Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/f636e48d41ac48a2a35b4d3c121c0723
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spelling	oai:doaj.org-article:f636e48d41ac48a2a35b4d3c121c07232021-12-02T12:59:21ZIs titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review2057-434710.1002/cre2.444https://doaj.org/article/f636e48d41ac48a2a35b4d3c121c07232021-12-01T00:00:00Zhttps://doi.org/10.1002/cre2.444https://doaj.org/toc/2057-4347Abstract Objectives Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systematic review aims to evaluate the effects of Ti‐6Al‐4 V on cells relevant to oral environments such as gingival fibroblasts. Materials and methods A literature search was undertaken for relevant English language publications in the following databases: Dental and Oral Science, Medline and Web of Science. The electronic search was supplemented with a search of references. Results After application of inclusion and exclusion criteria. A total of eight papers are included in this review. These papers were all in vitro studies and were categorized into whole implant, discs, or implant particles based on the type of test materials used in the studies. Conclusion Based on the analyses of the eight included studies in this review, if Ti‐6Al‐4 V as a material is unchallenged, i.e., as a whole implant in pH neutral environments, there appears to be little effect on fibroblasts. If Ti‐6Al‐4 V is challenged through corrosion or wear (particle release), the subsequent release of vanadium and aluminium particles has an increased cytotoxic effect in vitro in comparison to commercially pure titanium, hence concerns should be raised in the clinical setting.Jonathan WillisSiwei LiSt John CreanFadi N. BarrakWileyarticlecytotoxicityimplantperi‐implantitisTi‐6Al‐4 V alloyDentistryRK1-715ENClinical and Experimental Dental Research, Vol 7, Iss 6, Pp 1037-1044 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytotoxicity implant peri‐implantitis Ti‐6Al‐4 V alloy Dentistry RK1-715
spellingShingle	cytotoxicity implant peri‐implantitis Ti‐6Al‐4 V alloy Dentistry RK1-715 Jonathan Willis Siwei Li St John Crean Fadi N. Barrak Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review
description	Abstract Objectives Grade V titanium alloy (Ti‐6Al‐4 V) is a well‐recognized metallic biomaterial for medical implants. There has been some controversy regarding the use of this alloy in medical devices in relation to the toxicity of vanadium. In Dentistry, Ti‐6Al‐4 V remains prevalent. This systematic review aims to evaluate the effects of Ti‐6Al‐4 V on cells relevant to oral environments such as gingival fibroblasts. Materials and methods A literature search was undertaken for relevant English language publications in the following databases: Dental and Oral Science, Medline and Web of Science. The electronic search was supplemented with a search of references. Results After application of inclusion and exclusion criteria. A total of eight papers are included in this review. These papers were all in vitro studies and were categorized into whole implant, discs, or implant particles based on the type of test materials used in the studies. Conclusion Based on the analyses of the eight included studies in this review, if Ti‐6Al‐4 V as a material is unchallenged, i.e., as a whole implant in pH neutral environments, there appears to be little effect on fibroblasts. If Ti‐6Al‐4 V is challenged through corrosion or wear (particle release), the subsequent release of vanadium and aluminium particles has an increased cytotoxic effect in vitro in comparison to commercially pure titanium, hence concerns should be raised in the clinical setting.
format	article
author	Jonathan Willis Siwei Li St John Crean Fadi N. Barrak
author_facet	Jonathan Willis Siwei Li St John Crean Fadi N. Barrak
author_sort	Jonathan Willis
title	Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review
title_short	Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review
title_full	Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review
title_fullStr	Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review
title_full_unstemmed	Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review
title_sort	is titanium alloy ti‐6al‐4 v cytotoxic to gingival fibroblasts—a systematic review
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/f636e48d41ac48a2a35b4d3c121c0723
work_keys_str_mv	AT jonathanwillis istitaniumalloyti6al4vcytotoxictogingivalfibroblastsasystematicreview AT siweili istitaniumalloyti6al4vcytotoxictogingivalfibroblastsasystematicreview AT stjohncrean istitaniumalloyti6al4vcytotoxictogingivalfibroblastsasystematicreview AT fadinbarrak istitaniumalloyti6al4vcytotoxictogingivalfibroblastsasystematicreview
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Is titanium alloy Ti‐6Al‐4 V cytotoxic to gingival fibroblasts—A systematic review

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