Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

Abstract Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstrate that the hepatic ERα is essential for the modulation of the activity of Agou...

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Autores principales:	Valeria Benedusi, Sara Della Torre, Nico Mitro, Donatella Caruso, Alessandra Oberto, Claire Tronel, Clara Meda, Adriana Maggi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f63ae611519f4eff8bfd3828c8cb5cee
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spelling	oai:doaj.org-article:f63ae611519f4eff8bfd3828c8cb5cee2021-12-02T12:31:50ZLiver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice10.1038/s41598-017-01393-02045-2322https://doaj.org/article/f63ae611519f4eff8bfd3828c8cb5cee2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01393-0https://doaj.org/toc/2045-2322Abstract Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstrate that the hepatic ERα is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet. Our results suggest that the alterations of hepatic lipid metabolism due to the lack of liver ERα activity are responsible for a neuroinflammatory status that induces refractoriness of AgRP neurons to reproductive and dietary stimuli. The study therefore points to the liver ERα as a necessary sensor for the coordination of systemic energy metabolism and reproductive functions.Valeria BenedusiSara Della TorreNico MitroDonatella CarusoAlessandra ObertoClaire TronelClara MedaAdriana MaggiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valeria Benedusi Sara Della Torre Nico Mitro Donatella Caruso Alessandra Oberto Claire Tronel Clara Meda Adriana Maggi Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
description	Abstract Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstrate that the hepatic ERα is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet. Our results suggest that the alterations of hepatic lipid metabolism due to the lack of liver ERα activity are responsible for a neuroinflammatory status that induces refractoriness of AgRP neurons to reproductive and dietary stimuli. The study therefore points to the liver ERα as a necessary sensor for the coordination of systemic energy metabolism and reproductive functions.
format	article
author	Valeria Benedusi Sara Della Torre Nico Mitro Donatella Caruso Alessandra Oberto Claire Tronel Clara Meda Adriana Maggi
author_facet	Valeria Benedusi Sara Della Torre Nico Mitro Donatella Caruso Alessandra Oberto Claire Tronel Clara Meda Adriana Maggi
author_sort	Valeria Benedusi
title	Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
title_short	Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
title_full	Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
title_fullStr	Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
title_full_unstemmed	Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
title_sort	liver erα regulates agrp neuronal activity in the arcuate nucleus of female mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f63ae611519f4eff8bfd3828c8cb5cee
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Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

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