Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study

Abstract Background The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of different inflammatory phenotypes among asthma patients in Jilin Province, C...

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Autores principales:	Bingqing Shi, Wei Li, Hongna Dong, Mengting Xu, Yuqiu Hao, Peng Gao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Asthma Inflammatory cell phenotypes Induced sputum Uncontrolled asthma Severe asthma Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/f63d141dc41743698bfd7c4d2a993c94
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spelling	oai:doaj.org-article:f63d141dc41743698bfd7c4d2a993c942021-11-14T12:37:17ZDistribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study10.1186/s12890-021-01722-01471-2466https://doaj.org/article/f63d141dc41743698bfd7c4d2a993c942021-11-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01722-0https://doaj.org/toc/1471-2466Abstract Background The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of different inflammatory phenotypes among asthma patients in Jilin Province, China. Methods A total of 255 patients with asthma were recruited from Jilin Province, China for this cross-sectional study. Each patient underwent sputum induction following clinical assessment and peripheral blood collection. Inflammatory phenotypes were classified according to the inflammatory cell counts in the sputum. Results Paucigranulocytic asthma (PGA) was the most common inflammatory phenotype (52.2%), followed by eosinophilic asthma (EA, 38.3%), mixed granulocytic asthma (MGA, 5.2%), and neutrophilic asthma (NA, 4.3%). NA was more common among patients over 45 years old and those who were treated with higher doses of inhaled corticosteroids (ICS), but was less common following antibiotics treatment (p < 0.05). The proportion of patients with EA decreased as the ICS treatment dose and time increased (p = 0.038). Patients with uncontrolled asthma had higher numbers of sputum eosinophils and neutrophils (p < 0.05). Patients with severe asthma had a higher percentage of sputum neutrophils (p < 0.05). A greater proportion of patients with NA had severe asthma (60%) compared to those with EA (18.2%) (p = 0.016). Conclusions The most common asthma inflammatory cell phenotype in Jilin Province, China is PGA, followed by EA, MGA, and NA. The low prevalence of NA in Jilin Province compared to other countries and also other regions in China might be due to excessive antibiotic use and irregular ICS treatment in this region.Bingqing ShiWei LiHongna DongMengting XuYuqiu HaoPeng GaoBMCarticleAsthmaInflammatory cell phenotypesInduced sputumUncontrolled asthmaSevere asthmaDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asthma Inflammatory cell phenotypes Induced sputum Uncontrolled asthma Severe asthma Diseases of the respiratory system RC705-779
spellingShingle	Asthma Inflammatory cell phenotypes Induced sputum Uncontrolled asthma Severe asthma Diseases of the respiratory system RC705-779 Bingqing Shi Wei Li Hongna Dong Mengting Xu Yuqiu Hao Peng Gao Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study
description	Abstract Background The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of different inflammatory phenotypes among asthma patients in Jilin Province, China. Methods A total of 255 patients with asthma were recruited from Jilin Province, China for this cross-sectional study. Each patient underwent sputum induction following clinical assessment and peripheral blood collection. Inflammatory phenotypes were classified according to the inflammatory cell counts in the sputum. Results Paucigranulocytic asthma (PGA) was the most common inflammatory phenotype (52.2%), followed by eosinophilic asthma (EA, 38.3%), mixed granulocytic asthma (MGA, 5.2%), and neutrophilic asthma (NA, 4.3%). NA was more common among patients over 45 years old and those who were treated with higher doses of inhaled corticosteroids (ICS), but was less common following antibiotics treatment (p < 0.05). The proportion of patients with EA decreased as the ICS treatment dose and time increased (p = 0.038). Patients with uncontrolled asthma had higher numbers of sputum eosinophils and neutrophils (p < 0.05). Patients with severe asthma had a higher percentage of sputum neutrophils (p < 0.05). A greater proportion of patients with NA had severe asthma (60%) compared to those with EA (18.2%) (p = 0.016). Conclusions The most common asthma inflammatory cell phenotype in Jilin Province, China is PGA, followed by EA, MGA, and NA. The low prevalence of NA in Jilin Province compared to other countries and also other regions in China might be due to excessive antibiotic use and irregular ICS treatment in this region.
format	article
author	Bingqing Shi Wei Li Hongna Dong Mengting Xu Yuqiu Hao Peng Gao
author_facet	Bingqing Shi Wei Li Hongna Dong Mengting Xu Yuqiu Hao Peng Gao
author_sort	Bingqing Shi
title	Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study
title_short	Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study
title_full	Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study
title_fullStr	Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study
title_full_unstemmed	Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study
title_sort	distribution of inflammatory phenotypes among patients with asthma in jilin province, china: a cross-sectional study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f63d141dc41743698bfd7c4d2a993c94
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Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study

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