Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study

Diego Arauna,1,* Alvaro Cerda,2,3,* José Francisco García-García,4 Sergio Wehinger,1 Felipe Castro,5 Diego Méndez,1 Marcelo Alarcón,1 Eduardo Fuentes,1,2 Iván Palomo1,2 1Thrombosis Research Center, Department of Clinical Biochemistry...

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Autores principales:	Arauna D, Cerda A, García-García JF, Wehinger S, Castro F, Méndez D, Alarcón M, Fuentes E, Palomo I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	frailty polypharmacy chronic disease older adults aging Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f64040509bad407ea1d9404fa975437f
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spelling	oai:doaj.org-article:f64040509bad407ea1d9404fa975437f2021-12-02T11:39:40ZPolypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study1178-1998https://doaj.org/article/f64040509bad407ea1d9404fa975437f2020-06-01T00:00:00Zhttps://www.dovepress.com/polypharmacy-is-associated-with-frailty-nutritional-risk-and-chronic-d-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Diego Arauna,1,* Alvaro Cerda,2,3,* José Francisco García-García,4 Sergio Wehinger,1 Felipe Castro,5 Diego Méndez,1 Marcelo Alarcón,1 Eduardo Fuentes,1,2 Iván Palomo1,2 1Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Interdisciplinary Center on Aging, Universidad de Talca, Talca, Chile; 2Thematic Task Force on Healthy Aging, CUECH Research Network, Viña Del Mar, Chile; 3Center of Excellence in Translational Medicine, CEMT-BIOREN, Department of Basic Sciences, Universidad de la Frontera, Temuco, Chile; 4Department of Geriatric Medicine, Complejo Hospitalario de Toledo, Toledo, Spain; 5School of Medicine, Universidad de Talca, Talca, Chile*These authors contributed equally to this workCorrespondence: Eduardo Fuentes; Iván Palomo Email edfuentes@utalca.cl; ipalomo@utalca.clAim: To analyze the relationship between polypharmacy and variables as frailty and other chronic comorbidities in Chilean older adults.Design: Cross-sectional study.Participants: One thousand two hundred and five older adults aged 65 and older.Methods: The presence or absence of frailty syndrome was determined according to Fried criteria. Data collection was made through questionnaires conducted by an interview.Results: The prevalence of polypharmacy was 37.59%. The prevalence of hyperpolypharmacy was 2%. Increased prevalence of frailty was demonstrated regarding the progression of the state of polypharmacy. When analyzing the contribution of frailty respect polypharmacy condition, frail state, nutritional risk and obesity are founded as a factor associated with polypharmacy. Regarding chronic disease, hypertension (OR: 8.039, p< 0.0001), type 2 diabetes (OR: 4.001, p< 0.0001) and respiratory diseases (OR: 2.930, p< 0.0001) were associated to polypharmacy. It was found a strong and significant positive correlation between polypharmacy prevalence and frailty score (polypharmacy condition, Spearman R: 0.89, p=0.033; hyperpolypharmacy condition, Spearman R: 0.94, p=0.016). When analyzing the contribution of the polypharmacy to the presence of frailty, polypharmacy condition (OR: 1.510, p< 0.05), cognitive impairment (OR: 3.887, p< 0.001), obesity (OR: 1.560, p< 0.01) and nutritional risk (OR: 2.590, p< 0.001) are associated to frailty.Conclusion: Frailty and chronic conditions as nutritional risk, obesity, hypertension, type 2 diabetes and respiratory disease are an important risk factor for the development of polypharmacy in Chilean older adults. Likewise, polypharmacy condition was observed to be a risk factor for frailty, demonstrating the bidirectional relationship between both conditions. Frailty syndrome evaluation in Chilean older adults could be an important alternative for polypharmacy prevention.Keywords: frailty, polypharmacy, chronic disease, older adults, agingArauna DCerda AGarcía-García JFWehinger SCastro FMéndez DAlarcón MFuentes EPalomo IDove Medical Pressarticlefrailtypolypharmacychronic diseaseolder adultsagingGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 1013-1022 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty polypharmacy chronic disease older adults aging Geriatrics RC952-954.6
spellingShingle	frailty polypharmacy chronic disease older adults aging Geriatrics RC952-954.6 Arauna D Cerda A García-García JF Wehinger S Castro F Méndez D Alarcón M Fuentes E Palomo I Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
description	Diego Arauna,1,* Alvaro Cerda,2,3,* José Francisco García-García,4 Sergio Wehinger,1 Felipe Castro,5 Diego Méndez,1 Marcelo Alarcón,1 Eduardo Fuentes,1,2 Iván Palomo1,2 1Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Interdisciplinary Center on Aging, Universidad de Talca, Talca, Chile; 2Thematic Task Force on Healthy Aging, CUECH Research Network, Viña Del Mar, Chile; 3Center of Excellence in Translational Medicine, CEMT-BIOREN, Department of Basic Sciences, Universidad de la Frontera, Temuco, Chile; 4Department of Geriatric Medicine, Complejo Hospitalario de Toledo, Toledo, Spain; 5School of Medicine, Universidad de Talca, Talca, Chile*These authors contributed equally to this workCorrespondence: Eduardo Fuentes; Iván Palomo Email edfuentes@utalca.cl; ipalomo@utalca.clAim: To analyze the relationship between polypharmacy and variables as frailty and other chronic comorbidities in Chilean older adults.Design: Cross-sectional study.Participants: One thousand two hundred and five older adults aged 65 and older.Methods: The presence or absence of frailty syndrome was determined according to Fried criteria. Data collection was made through questionnaires conducted by an interview.Results: The prevalence of polypharmacy was 37.59%. The prevalence of hyperpolypharmacy was 2%. Increased prevalence of frailty was demonstrated regarding the progression of the state of polypharmacy. When analyzing the contribution of frailty respect polypharmacy condition, frail state, nutritional risk and obesity are founded as a factor associated with polypharmacy. Regarding chronic disease, hypertension (OR: 8.039, p< 0.0001), type 2 diabetes (OR: 4.001, p< 0.0001) and respiratory diseases (OR: 2.930, p< 0.0001) were associated to polypharmacy. It was found a strong and significant positive correlation between polypharmacy prevalence and frailty score (polypharmacy condition, Spearman R: 0.89, p=0.033; hyperpolypharmacy condition, Spearman R: 0.94, p=0.016). When analyzing the contribution of the polypharmacy to the presence of frailty, polypharmacy condition (OR: 1.510, p< 0.05), cognitive impairment (OR: 3.887, p< 0.001), obesity (OR: 1.560, p< 0.01) and nutritional risk (OR: 2.590, p< 0.001) are associated to frailty.Conclusion: Frailty and chronic conditions as nutritional risk, obesity, hypertension, type 2 diabetes and respiratory disease are an important risk factor for the development of polypharmacy in Chilean older adults. Likewise, polypharmacy condition was observed to be a risk factor for frailty, demonstrating the bidirectional relationship between both conditions. Frailty syndrome evaluation in Chilean older adults could be an important alternative for polypharmacy prevention.Keywords: frailty, polypharmacy, chronic disease, older adults, aging
format	article
author	Arauna D Cerda A García-García JF Wehinger S Castro F Méndez D Alarcón M Fuentes E Palomo I
author_facet	Arauna D Cerda A García-García JF Wehinger S Castro F Méndez D Alarcón M Fuentes E Palomo I
author_sort	Arauna D
title	Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
title_short	Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
title_full	Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
title_fullStr	Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
title_full_unstemmed	Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study
title_sort	polypharmacy is associated with frailty, nutritional risk and chronic disease in chilean older adults: remarks from piei-es study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f64040509bad407ea1d9404fa975437f
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Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study

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