Immunosuppressant flavonoids from Scutellaria baicalensis

Some plants used in Traditional Chinese Medicine serve as treatment for disease states where a suppression of the cellular immune response is desired. However, the compounds responsible for the immunosuppressant effects of these plants are not necessarily known.The immunosuppressant compounds in the...

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Autores principales:	Nova Syafni, Seema Devi, Amy M. Zimmermann-Klemd, Jakob K. Reinhardt, Ombeline Danton, Carsten Gründemann, Matthias Hamburger
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Scutellaria baicalensis T-lymphocyte proliferation Immunosuppressant activity HPLC based activity profiling Flavonoids Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f6413e291ff84b29afbcb5b6baaf31a1
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id	oai:doaj.org-article:f6413e291ff84b29afbcb5b6baaf31a1
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spelling	oai:doaj.org-article:f6413e291ff84b29afbcb5b6baaf31a12021-11-14T04:29:43ZImmunosuppressant flavonoids from Scutellaria baicalensis0753-332210.1016/j.biopha.2021.112326https://doaj.org/article/f6413e291ff84b29afbcb5b6baaf31a12021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011100https://doaj.org/toc/0753-3322Some plants used in Traditional Chinese Medicine serve as treatment for disease states where a suppression of the cellular immune response is desired. However, the compounds responsible for the immunosuppressant effects of these plants are not necessarily known.The immunosuppressant compounds in the roots of Scutellaria baicalensis, one of the most promising plants identified in a previous screening, were tracked by HPLC activity profiling and concomitant on-line spectroscopic analysis. Compounds were then isolated by preparative chromatography, and structures elucidated by spectroscopic methods. Twelve flavonoids (5–16) were identified from the active time windows, and structurally related flavones 2, 4, and 17, and flavanones 1 and 3 were isolated from adjacent fractions. All flavonoids possessed an unusual substitution pattern on the B-ring, with an absence of substituents at C-3 and C-4. Compounds 11, 13, 14, and 16 inhibited T-cell proliferation (IC50 values at 12.1–39 μM) at non-cytotoxic concentrations. The findings may support the use of S. baicalensis in disorders where a modulation of the cellular immune response is desirable.Nova SyafniSeema DeviAmy M. Zimmermann-KlemdJakob K. ReinhardtOmbeline DantonCarsten GründemannMatthias HamburgerElsevierarticleScutellaria baicalensisT-lymphocyte proliferationImmunosuppressant activityHPLC based activity profilingFlavonoidsTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112326- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Scutellaria baicalensis T-lymphocyte proliferation Immunosuppressant activity HPLC based activity profiling Flavonoids Therapeutics. Pharmacology RM1-950
spellingShingle	Scutellaria baicalensis T-lymphocyte proliferation Immunosuppressant activity HPLC based activity profiling Flavonoids Therapeutics. Pharmacology RM1-950 Nova Syafni Seema Devi Amy M. Zimmermann-Klemd Jakob K. Reinhardt Ombeline Danton Carsten Gründemann Matthias Hamburger Immunosuppressant flavonoids from Scutellaria baicalensis
description	Some plants used in Traditional Chinese Medicine serve as treatment for disease states where a suppression of the cellular immune response is desired. However, the compounds responsible for the immunosuppressant effects of these plants are not necessarily known.The immunosuppressant compounds in the roots of Scutellaria baicalensis, one of the most promising plants identified in a previous screening, were tracked by HPLC activity profiling and concomitant on-line spectroscopic analysis. Compounds were then isolated by preparative chromatography, and structures elucidated by spectroscopic methods. Twelve flavonoids (5–16) were identified from the active time windows, and structurally related flavones 2, 4, and 17, and flavanones 1 and 3 were isolated from adjacent fractions. All flavonoids possessed an unusual substitution pattern on the B-ring, with an absence of substituents at C-3 and C-4. Compounds 11, 13, 14, and 16 inhibited T-cell proliferation (IC50 values at 12.1–39 μM) at non-cytotoxic concentrations. The findings may support the use of S. baicalensis in disorders where a modulation of the cellular immune response is desirable.
format	article
author	Nova Syafni Seema Devi Amy M. Zimmermann-Klemd Jakob K. Reinhardt Ombeline Danton Carsten Gründemann Matthias Hamburger
author_facet	Nova Syafni Seema Devi Amy M. Zimmermann-Klemd Jakob K. Reinhardt Ombeline Danton Carsten Gründemann Matthias Hamburger
author_sort	Nova Syafni
title	Immunosuppressant flavonoids from Scutellaria baicalensis
title_short	Immunosuppressant flavonoids from Scutellaria baicalensis
title_full	Immunosuppressant flavonoids from Scutellaria baicalensis
title_fullStr	Immunosuppressant flavonoids from Scutellaria baicalensis
title_full_unstemmed	Immunosuppressant flavonoids from Scutellaria baicalensis
title_sort	immunosuppressant flavonoids from scutellaria baicalensis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f6413e291ff84b29afbcb5b6baaf31a1
work_keys_str_mv	AT novasyafni immunosuppressantflavonoidsfromscutellariabaicalensis AT seemadevi immunosuppressantflavonoidsfromscutellariabaicalensis AT amymzimmermannklemd immunosuppressantflavonoidsfromscutellariabaicalensis AT jakobkreinhardt immunosuppressantflavonoidsfromscutellariabaicalensis AT ombelinedanton immunosuppressantflavonoidsfromscutellariabaicalensis AT carstengrundemann immunosuppressantflavonoidsfromscutellariabaicalensis AT matthiashamburger immunosuppressantflavonoidsfromscutellariabaicalensis
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Immunosuppressant flavonoids from Scutellaria baicalensis

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