Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1

Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1

Most breast cancer patients are estrogen receptor positive and thus benefit from treatments that inhibit estrogen production; however, one third of tamoxifen-treated patients develops resistance and relapse. Here the authors show that tamoxifen resistant cells are resistant to chemotherapy because o...

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Autores principales: Yinghua Zhu, Yujie Liu, Chao Zhang, Junjun Chu, Yanqing Wu, Yudong Li, Jieqiong Liu, Qian Li, Shunying Li, Qianfeng Shi, Liang Jin, Jianli Zhao, Dong Yin, Sol Efroni, Fengxi Su, Herui Yao, Erwei Song, Qiang Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f641a224086d4d8bbeff596666286a34
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spelling oai:doaj.org-article:f641a224086d4d8bbeff596666286a342021-12-02T16:50:11ZTamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA110.1038/s41467-018-03951-02041-1723https://doaj.org/article/f641a224086d4d8bbeff596666286a342018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03951-0https://doaj.org/toc/2041-1723Most breast cancer patients are estrogen receptor positive and thus benefit from treatments that inhibit estrogen production; however, one third of tamoxifen-treated patients develops resistance and relapse. Here the authors show that tamoxifen resistant cells are resistant to chemotherapy because of BARD1 and BRCA1 upregulation.Yinghua ZhuYujie LiuChao ZhangJunjun ChuYanqing WuYudong LiJieqiong LiuQian LiShunying LiQianfeng ShiLiang JinJianli ZhaoDong YinSol EfroniFengxi SuHerui YaoErwei SongQiang LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yinghua Zhu
Yujie Liu
Chao Zhang
Junjun Chu
Yanqing Wu
Yudong Li
Jieqiong Liu
Qian Li
Shunying Li
Qianfeng Shi
Liang Jin
Jianli Zhao
Dong Yin
Sol Efroni
Fengxi Su
Herui Yao
Erwei Song
Qiang Liu
Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1
description Most breast cancer patients are estrogen receptor positive and thus benefit from treatments that inhibit estrogen production; however, one third of tamoxifen-treated patients develops resistance and relapse. Here the authors show that tamoxifen resistant cells are resistant to chemotherapy because of BARD1 and BRCA1 upregulation.
format article
author Yinghua Zhu
Yujie Liu
Chao Zhang
Junjun Chu
Yanqing Wu
Yudong Li
Jieqiong Liu
Qian Li
Shunying Li
Qianfeng Shi
Liang Jin
Jianli Zhao
Dong Yin
Sol Efroni
Fengxi Su
Herui Yao
Erwei Song
Qiang Liu
author_facet Yinghua Zhu
Yujie Liu
Chao Zhang
Junjun Chu
Yanqing Wu
Yudong Li
Jieqiong Liu
Qian Li
Shunying Li
Qianfeng Shi
Liang Jin
Jianli Zhao
Dong Yin
Sol Efroni
Fengxi Su
Herui Yao
Erwei Song
Qiang Liu
author_sort Yinghua Zhu
title Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1
title_short Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1
title_full Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1
title_fullStr Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1
title_full_unstemmed Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1
title_sort tamoxifen-resistant breast cancer cells are resistant to dna-damaging chemotherapy because of upregulated bard1 and brca1
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f641a224086d4d8bbeff596666286a34
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