Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Abstract Raised circulating concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), have been reported in several rheumatic diseases (RDs). However, the strength of this relationship is unclear. Therefore, the aim of this systematic review and me...

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Autores principales:	Gian Luca Erre, Arduino Aleksander Mangoni, Floriana Castagna, Panagiotis Paliogiannis, Ciriaco Carru, Giuseppe Passiu, Angelo Zinellu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6440188647c475a9e578e3f21804d37
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spelling	oai:doaj.org-article:f6440188647c475a9e578e3f21804d372021-12-02T15:09:54ZMeta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases10.1038/s41598-019-41994-52045-2322https://doaj.org/article/f6440188647c475a9e578e3f21804d372019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-41994-5https://doaj.org/toc/2045-2322Abstract Raised circulating concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), have been reported in several rheumatic diseases (RDs). However, the strength of this relationship is unclear. Therefore, the aim of this systematic review and meta-analysis was to evaluate the magnitude and the robustness of the association between ADMA concentrations and RDs. We calculated standardized mean differences (SMD, with 95% confidence intervals, CI). Study heterogeneity was evaluated by meta-regressions and sensitivity analyses according to type of RDs, conventional cardiovascular risk factors, inflammatory markers, and type of ADMA assessment methodology. Thirty-seven studies with a total of 2,982 subjects (1,860 RDs patients and 1,122 healthy controls) were included in our meta-analysis. Pooled results showed that ADMA concentrations were significantly higher in patients with RDs than in healthy controls (SMD = 1.27 µmol/L, 95% CI 0.94–1.60 µmol/L; p < 0.001). However, the between-studies heterogeneity was high. Differences in ADMA concentrations between controls and RDs patients were not significantly associated with inflammatory markers, increasing age, lipid concentrations, body mass index, blood pressure, or methodology used to assess ADMA. Furthermore, subgroup analysis showed no difference across RDs. This meta-analysis showed that, in the context of significant between-study heterogeneity, circulating concentrations of ADMA are positively related to RDs.Gian Luca ErreArduino Aleksander MangoniFloriana CastagnaPanagiotis PaliogiannisCiriaco CarruGiuseppe PassiuAngelo ZinelluNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gian Luca Erre Arduino Aleksander Mangoni Floriana Castagna Panagiotis Paliogiannis Ciriaco Carru Giuseppe Passiu Angelo Zinellu Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases
description	Abstract Raised circulating concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), have been reported in several rheumatic diseases (RDs). However, the strength of this relationship is unclear. Therefore, the aim of this systematic review and meta-analysis was to evaluate the magnitude and the robustness of the association between ADMA concentrations and RDs. We calculated standardized mean differences (SMD, with 95% confidence intervals, CI). Study heterogeneity was evaluated by meta-regressions and sensitivity analyses according to type of RDs, conventional cardiovascular risk factors, inflammatory markers, and type of ADMA assessment methodology. Thirty-seven studies with a total of 2,982 subjects (1,860 RDs patients and 1,122 healthy controls) were included in our meta-analysis. Pooled results showed that ADMA concentrations were significantly higher in patients with RDs than in healthy controls (SMD = 1.27 µmol/L, 95% CI 0.94–1.60 µmol/L; p < 0.001). However, the between-studies heterogeneity was high. Differences in ADMA concentrations between controls and RDs patients were not significantly associated with inflammatory markers, increasing age, lipid concentrations, body mass index, blood pressure, or methodology used to assess ADMA. Furthermore, subgroup analysis showed no difference across RDs. This meta-analysis showed that, in the context of significant between-study heterogeneity, circulating concentrations of ADMA are positively related to RDs.
format	article
author	Gian Luca Erre Arduino Aleksander Mangoni Floriana Castagna Panagiotis Paliogiannis Ciriaco Carru Giuseppe Passiu Angelo Zinellu
author_facet	Gian Luca Erre Arduino Aleksander Mangoni Floriana Castagna Panagiotis Paliogiannis Ciriaco Carru Giuseppe Passiu Angelo Zinellu
author_sort	Gian Luca Erre
title	Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases
title_short	Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases
title_full	Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases
title_fullStr	Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases
title_full_unstemmed	Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases
title_sort	meta-analysis of asymmetric dimethylarginine concentrations in rheumatic diseases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f6440188647c475a9e578e3f21804d37
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Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

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