Synthesis and characterization of gold nanorods and their application for photothermal cell damage

Mohd Samim1, CK Prashant2, AK Dinda2, AN Maitra3, Indu Arora41Department of Chemistry, Hamdard University, Hamdard Nagar; 2Department of Pathology, All India Institute of Medical Sciences, New Delhi; 3Department of Chemistry, University of Delhi, Delhi, India; 4Department of Biomedical Sciences, Sha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samim M, Prashant CK, Dinda AK, Maitra AN, Arora I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f655fa448a5b455da32c2564577bdfba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f655fa448a5b455da32c2564577bdfba
record_format	dspace
spelling	oai:doaj.org-article:f655fa448a5b455da32c2564577bdfba2021-12-02T03:17:09ZSynthesis and characterization of gold nanorods and their application for photothermal cell damage1176-91141178-2013https://doaj.org/article/f655fa448a5b455da32c2564577bdfba2011-08-01T00:00:00Zhttp://www.dovepress.com/synthesis-and-characterization-of-gold-nanorods-and-their-application--a8184https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mohd Samim1, CK Prashant2, AK Dinda2, AN Maitra3, Indu Arora41Department of Chemistry, Hamdard University, Hamdard Nagar; 2Department of Pathology, All India Institute of Medical Sciences, New Delhi; 3Department of Chemistry, University of Delhi, Delhi, India; 4Department of Biomedical Sciences, Shaeed Rajguru College of Applied Sciences, University of Delhi, Delhi, IndiaBackground: Gold nanorods show a surface plasmon resonance (SPR) band at the near infra-red (NIR) region which enables them to produce heat on irradiation with a NIR laser. As a result of this, gold nanorods have the potential to be used as thermal therapeutic agents for selective damage to cancer cells, bacterial cells, viruses, and DNA.Methods: Gold nanorods with an aspect ratio of approximately 5 were prepared by exploiting the normal micellar route of a water/dioctyl sulfosuccinate (Aerosol-T)/hexane system. The shape and size of the gold nanorods were characterized by surface plasmon bands at 520 nm and 980 nm, and by atomic force microscopy and transmission electron microscopy.Results: The length of the gold nanorods was 100 nm and their diameter was 20 nm. X-ray diffraction analysis demonstrated that the gold nanorods formed were metallic in nature. The gold nanorods showed good photothermolysis activity.Conclusion: Gold nanorods injected subcutaneously and irradiated with 980 nm laser caused injury to rat tissue, demonstrating that gold nanorods may be used to kill cancerous cells in tumor tissue.Keywords: nanorods, gold, micellar system, photothermolysisSamim MPrashant CKDinda AKMaitra ANArora IDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1825-1831 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Samim M Prashant CK Dinda AK Maitra AN Arora I Synthesis and characterization of gold nanorods and their application for photothermal cell damage
description	Mohd Samim1, CK Prashant2, AK Dinda2, AN Maitra3, Indu Arora41Department of Chemistry, Hamdard University, Hamdard Nagar; 2Department of Pathology, All India Institute of Medical Sciences, New Delhi; 3Department of Chemistry, University of Delhi, Delhi, India; 4Department of Biomedical Sciences, Shaeed Rajguru College of Applied Sciences, University of Delhi, Delhi, IndiaBackground: Gold nanorods show a surface plasmon resonance (SPR) band at the near infra-red (NIR) region which enables them to produce heat on irradiation with a NIR laser. As a result of this, gold nanorods have the potential to be used as thermal therapeutic agents for selective damage to cancer cells, bacterial cells, viruses, and DNA.Methods: Gold nanorods with an aspect ratio of approximately 5 were prepared by exploiting the normal micellar route of a water/dioctyl sulfosuccinate (Aerosol-T)/hexane system. The shape and size of the gold nanorods were characterized by surface plasmon bands at 520 nm and 980 nm, and by atomic force microscopy and transmission electron microscopy.Results: The length of the gold nanorods was 100 nm and their diameter was 20 nm. X-ray diffraction analysis demonstrated that the gold nanorods formed were metallic in nature. The gold nanorods showed good photothermolysis activity.Conclusion: Gold nanorods injected subcutaneously and irradiated with 980 nm laser caused injury to rat tissue, demonstrating that gold nanorods may be used to kill cancerous cells in tumor tissue.Keywords: nanorods, gold, micellar system, photothermolysis
format	article
author	Samim M Prashant CK Dinda AK Maitra AN Arora I
author_facet	Samim M Prashant CK Dinda AK Maitra AN Arora I
author_sort	Samim M
title	Synthesis and characterization of gold nanorods and their application for photothermal cell damage
title_short	Synthesis and characterization of gold nanorods and their application for photothermal cell damage
title_full	Synthesis and characterization of gold nanorods and their application for photothermal cell damage
title_fullStr	Synthesis and characterization of gold nanorods and their application for photothermal cell damage
title_full_unstemmed	Synthesis and characterization of gold nanorods and their application for photothermal cell damage
title_sort	synthesis and characterization of gold nanorods and their application for photothermal cell damage
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/f655fa448a5b455da32c2564577bdfba
work_keys_str_mv	AT samimm synthesisandcharacterizationofgoldnanorodsandtheirapplicationforphotothermalcelldamage AT prashantck synthesisandcharacterizationofgoldnanorodsandtheirapplicationforphotothermalcelldamage AT dindaak synthesisandcharacterizationofgoldnanorodsandtheirapplicationforphotothermalcelldamage AT maitraan synthesisandcharacterizationofgoldnanorodsandtheirapplicationforphotothermalcelldamage AT arorai synthesisandcharacterizationofgoldnanorodsandtheirapplicationforphotothermalcelldamage
_version_	1718401896655355904

Synthesis and characterization of gold nanorods and their application for photothermal cell damage

Ejemplares similares