Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study

Ameena Alyazeedi,1 Ahmed Fouad Algendy,2 Mohamed Sharabash,3 Ahmed Karawia4 1Pharmacy Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 2Clinical Pharmacy, Geriatric Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 3Clinical Pharmacy, Rumailah Hospital, Ham...

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Autores principales:	Alyazeedi A, Fouad Algendy A, Sharabash M, Karawia A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	polypharmacy beers 2019 falls constipation emergency admission fracture Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f6582645f90a4155a6cf49cfeca85c4a
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spelling	oai:doaj.org-article:f6582645f90a4155a6cf49cfeca85c4a2021-12-02T06:15:31ZPrevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study1178-1998https://doaj.org/article/f6582645f90a4155a6cf49cfeca85c4a2019-11-01T00:00:00Zhttps://www.dovepress.com/prevalence-determinants-and-associated-risk-of-potentially-inappropria-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ameena Alyazeedi,1 Ahmed Fouad Algendy,2 Mohamed Sharabash,3 Ahmed Karawia4 1Pharmacy Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 2Clinical Pharmacy, Geriatric Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 3Clinical Pharmacy, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 4Pharmacy Informatics and Inventory, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarCorrespondence: Ahmed Fouad AlgendyPharmacy Department, Rumailah Hospital, Hamad Medical Corporation, PO 3050, Doha, QatarTel +97470094424Fax +97444397600Email amohamed89@hamad.qaPurpose: To assess the prevalence and associated risk of potentially inappropriate prescribing (PIP) in older adults.Methods: This was a national 3-year retrospective study of outpatient older adults exposed to potentially inappropriate medication (PIM) or polypharmacy. We used the Beers Criteria 2019 list to identify PIM to be avoided in older adults. We define moderate polypharmacy (MoP) and major polypharmacy (MaP) as using 6–10 or >10 chronic medications, respectively. Determinants of PIP included patients’ demographics, lab results, medications, comorbidities, and home healthcare services. We used Chi-square (for categorical variables), Unpaired t-test and ANOVA (for continuous variables as applicable) to assess the association of these determinants with PIP. Univariate followed by multivariate logistic regression models were used to get the crude and adjusted odds ratios of exposure to PIM or polypharmacy within patients who had emergency department (ED) admissions, bone fractures, falls, or constipation, compared to those who had not.Results: 3537 patients were included. 62.6%, 40.4%, and 27.2% were exposed to PIM, MoP and MaP, respectively. Determinants of PIP included age, gender, ethnicity, weight, kidney function, sodium levels, hypertension, diabetes, heart failure, CAD, and home healthcare services (all with p-value < 0.05). PIM was associated with risk of ED admission, bone fracture and constipation with adjusted OR (p-values) of 1.27 (0.002), 1.33 (0.005), and 1.40 (<0.001), respectively. MoP was associated with the risk of ED admission, bone fracture, and constipation, with adjusted OR (p-values) of 1.27 (0.012), 1.34 (0.019), and 1.47 (<0.001), respectively. MaP was associated with a higher risk of ED admission, bone fracture, falls, and constipation with adjusted OR (p-values) of 1.46 (0.001), 1.59 (0.002), 1.39 (0.023), and 2.07 (<0.001), respectively.Conclusion: PIP is common and is associated with an increased risk of poor clinical outcomes in older adults.Keywords: polypharmacy, Beers 2019, falls, constipation, emergency admission, fractureAlyazeedi AFouad Algendy ASharabash MKarawia ADove Medical Pressarticlepolypharmacybeers 2019fallsconstipationemergency admissionfractureGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1889-1899 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	polypharmacy beers 2019 falls constipation emergency admission fracture Geriatrics RC952-954.6
spellingShingle	polypharmacy beers 2019 falls constipation emergency admission fracture Geriatrics RC952-954.6 Alyazeedi A Fouad Algendy A Sharabash M Karawia A Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study
description	Ameena Alyazeedi,1 Ahmed Fouad Algendy,2 Mohamed Sharabash,3 Ahmed Karawia4 1Pharmacy Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 2Clinical Pharmacy, Geriatric Department, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 3Clinical Pharmacy, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar; 4Pharmacy Informatics and Inventory, Rumailah Hospital, Hamad Medical Corporation, Doha, QatarCorrespondence: Ahmed Fouad AlgendyPharmacy Department, Rumailah Hospital, Hamad Medical Corporation, PO 3050, Doha, QatarTel +97470094424Fax +97444397600Email amohamed89@hamad.qaPurpose: To assess the prevalence and associated risk of potentially inappropriate prescribing (PIP) in older adults.Methods: This was a national 3-year retrospective study of outpatient older adults exposed to potentially inappropriate medication (PIM) or polypharmacy. We used the Beers Criteria 2019 list to identify PIM to be avoided in older adults. We define moderate polypharmacy (MoP) and major polypharmacy (MaP) as using 6–10 or >10 chronic medications, respectively. Determinants of PIP included patients’ demographics, lab results, medications, comorbidities, and home healthcare services. We used Chi-square (for categorical variables), Unpaired t-test and ANOVA (for continuous variables as applicable) to assess the association of these determinants with PIP. Univariate followed by multivariate logistic regression models were used to get the crude and adjusted odds ratios of exposure to PIM or polypharmacy within patients who had emergency department (ED) admissions, bone fractures, falls, or constipation, compared to those who had not.Results: 3537 patients were included. 62.6%, 40.4%, and 27.2% were exposed to PIM, MoP and MaP, respectively. Determinants of PIP included age, gender, ethnicity, weight, kidney function, sodium levels, hypertension, diabetes, heart failure, CAD, and home healthcare services (all with p-value < 0.05). PIM was associated with risk of ED admission, bone fracture and constipation with adjusted OR (p-values) of 1.27 (0.002), 1.33 (0.005), and 1.40 (<0.001), respectively. MoP was associated with the risk of ED admission, bone fracture, and constipation, with adjusted OR (p-values) of 1.27 (0.012), 1.34 (0.019), and 1.47 (<0.001), respectively. MaP was associated with a higher risk of ED admission, bone fracture, falls, and constipation with adjusted OR (p-values) of 1.46 (0.001), 1.59 (0.002), 1.39 (0.023), and 2.07 (<0.001), respectively.Conclusion: PIP is common and is associated with an increased risk of poor clinical outcomes in older adults.Keywords: polypharmacy, Beers 2019, falls, constipation, emergency admission, fracture
format	article
author	Alyazeedi A Fouad Algendy A Sharabash M Karawia A
author_facet	Alyazeedi A Fouad Algendy A Sharabash M Karawia A
author_sort	Alyazeedi A
title	Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study
title_short	Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study
title_full	Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study
title_fullStr	Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study
title_full_unstemmed	Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study
title_sort	prevalence, determinants and associated risk of potentially inappropriate prescribing for older adults in qatar: a national retrospective study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f6582645f90a4155a6cf49cfeca85c4a
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Prevalence, Determinants And Associated Risk Of Potentially Inappropriate Prescribing For Older Adults In Qatar: A National Retrospective Study

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