Receptor-binding loops in alphacoronavirus adaptation and evolution

Coronaviruses have a relatively high mutation rate, potentially allowing fast adaptation to changing pressures. Here, Wong et al. provide the structure of the receptor-binding domain (RBD) of the human coronavirus HCoV-229E and its receptor and analyze the evolution of the RBD over the past 50 years...

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Autores principales:	Alan H. M. Wong, Aidan C. A. Tomlinson, Dongxia Zhou, Malathy Satkunarajah, Kevin Chen, Chetna Sharon, Marc Desforges, Pierre J. Talbot, James M. Rini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f6588e45349a4419aa4c7ce1d24b3317
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spelling	oai:doaj.org-article:f6588e45349a4419aa4c7ce1d24b33172021-12-02T14:41:18ZReceptor-binding loops in alphacoronavirus adaptation and evolution10.1038/s41467-017-01706-x2041-1723https://doaj.org/article/f6588e45349a4419aa4c7ce1d24b33172017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01706-xhttps://doaj.org/toc/2041-1723Coronaviruses have a relatively high mutation rate, potentially allowing fast adaptation to changing pressures. Here, Wong et al. provide the structure of the receptor-binding domain (RBD) of the human coronavirus HCoV-229E and its receptor and analyze the evolution of the RBD over the past 50 years.Alan H. M. WongAidan C. A. TomlinsonDongxia ZhouMalathy SatkunarajahKevin ChenChetna SharonMarc DesforgesPierre J. TalbotJames M. RiniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alan H. M. Wong Aidan C. A. Tomlinson Dongxia Zhou Malathy Satkunarajah Kevin Chen Chetna Sharon Marc Desforges Pierre J. Talbot James M. Rini Receptor-binding loops in alphacoronavirus adaptation and evolution
description	Coronaviruses have a relatively high mutation rate, potentially allowing fast adaptation to changing pressures. Here, Wong et al. provide the structure of the receptor-binding domain (RBD) of the human coronavirus HCoV-229E and its receptor and analyze the evolution of the RBD over the past 50 years.
format	article
author	Alan H. M. Wong Aidan C. A. Tomlinson Dongxia Zhou Malathy Satkunarajah Kevin Chen Chetna Sharon Marc Desforges Pierre J. Talbot James M. Rini
author_facet	Alan H. M. Wong Aidan C. A. Tomlinson Dongxia Zhou Malathy Satkunarajah Kevin Chen Chetna Sharon Marc Desforges Pierre J. Talbot James M. Rini
author_sort	Alan H. M. Wong
title	Receptor-binding loops in alphacoronavirus adaptation and evolution
title_short	Receptor-binding loops in alphacoronavirus adaptation and evolution
title_full	Receptor-binding loops in alphacoronavirus adaptation and evolution
title_fullStr	Receptor-binding loops in alphacoronavirus adaptation and evolution
title_full_unstemmed	Receptor-binding loops in alphacoronavirus adaptation and evolution
title_sort	receptor-binding loops in alphacoronavirus adaptation and evolution
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f6588e45349a4419aa4c7ce1d24b3317
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Receptor-binding loops in alphacoronavirus adaptation and evolution

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