Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population.
Allergic rhinitis (AR) is an atopic disease which affects about 600 million people worldwide and results from a complex interplay between genetic and environmental factors. However genetic association studies on known candidate genes yielded variable results. The aim of this study is to identify the...
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Public Library of Science (PLoS)
2011
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oai:doaj.org-article:f659a63ac296475e9f9aed0ad1c7afc32021-11-18T06:53:32ZGenome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population.1932-620310.1371/journal.pone.0019719https://doaj.org/article/f659a63ac296475e9f9aed0ad1c7afc32011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21625490/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Allergic rhinitis (AR) is an atopic disease which affects about 600 million people worldwide and results from a complex interplay between genetic and environmental factors. However genetic association studies on known candidate genes yielded variable results. The aim of this study is to identify the genetic variants that influence predisposition towards allergic rhinitis in an ethnic Chinese population in Singapore using a genome-wide association study (GWAS) approach. A total of 4461 ethnic Chinese volunteers were recruited in Singapore and classified according to their allergic disease status. The GWAS included a discovery stage comparing 515 atopic cases (including 456 AR cases) and 486 non-allergic non-rhinitis (NANR) controls. The top SNPs were then validated in a replication cohort consisting of a separate 2323 atopic cases (including 676 AR cases) and 511 NANR controls. Two SNPs showed consistent association in both discovery and replication phases; MRPL4 SNP rs8111930 on 19q13.2 (OR = 0.69, P(combined) = 4.46×10(-05)) and BCAP SNP rs505010 on chromosome 10q24.1 (OR = 0.64, P(combined) = 1.10×10(-04)). In addition, we also replicated multiple associations within known candidates regions such as HLA-DQ and NPSR1 locus in the discovery phase. Our study suggests that MRPL4 and BCAP, key components of the HIF-1α and PI3K/Akt signaling pathways respectively, are two novel candidate genes for atopy and allergic rhinitis. Further study on these molecules and their signaling pathways would help in understanding of the pathogenesis of allergic rhinitis and identification of targets for new therapeutic intervention.Anand Kumar AndiappanDe Yun WangRamani AnantharamanPallavi Nilkanth ParateBani Kaur SuriHui Qi LowYi LiWanting ZhaoPaola CastagnoliJianjun LiuFook Tim ChewPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19719 (2011) |
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Medicine R Science Q Anand Kumar Andiappan De Yun Wang Ramani Anantharaman Pallavi Nilkanth Parate Bani Kaur Suri Hui Qi Low Yi Li Wanting Zhao Paola Castagnoli Jianjun Liu Fook Tim Chew Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. |
| description |
Allergic rhinitis (AR) is an atopic disease which affects about 600 million people worldwide and results from a complex interplay between genetic and environmental factors. However genetic association studies on known candidate genes yielded variable results. The aim of this study is to identify the genetic variants that influence predisposition towards allergic rhinitis in an ethnic Chinese population in Singapore using a genome-wide association study (GWAS) approach. A total of 4461 ethnic Chinese volunteers were recruited in Singapore and classified according to their allergic disease status. The GWAS included a discovery stage comparing 515 atopic cases (including 456 AR cases) and 486 non-allergic non-rhinitis (NANR) controls. The top SNPs were then validated in a replication cohort consisting of a separate 2323 atopic cases (including 676 AR cases) and 511 NANR controls. Two SNPs showed consistent association in both discovery and replication phases; MRPL4 SNP rs8111930 on 19q13.2 (OR = 0.69, P(combined) = 4.46×10(-05)) and BCAP SNP rs505010 on chromosome 10q24.1 (OR = 0.64, P(combined) = 1.10×10(-04)). In addition, we also replicated multiple associations within known candidates regions such as HLA-DQ and NPSR1 locus in the discovery phase. Our study suggests that MRPL4 and BCAP, key components of the HIF-1α and PI3K/Akt signaling pathways respectively, are two novel candidate genes for atopy and allergic rhinitis. Further study on these molecules and their signaling pathways would help in understanding of the pathogenesis of allergic rhinitis and identification of targets for new therapeutic intervention. |
| format |
article |
| author |
Anand Kumar Andiappan De Yun Wang Ramani Anantharaman Pallavi Nilkanth Parate Bani Kaur Suri Hui Qi Low Yi Li Wanting Zhao Paola Castagnoli Jianjun Liu Fook Tim Chew |
| author_facet |
Anand Kumar Andiappan De Yun Wang Ramani Anantharaman Pallavi Nilkanth Parate Bani Kaur Suri Hui Qi Low Yi Li Wanting Zhao Paola Castagnoli Jianjun Liu Fook Tim Chew |
| author_sort |
Anand Kumar Andiappan |
| title |
Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. |
| title_short |
Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. |
| title_full |
Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. |
| title_fullStr |
Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. |
| title_full_unstemmed |
Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population. |
| title_sort |
genome-wide association study for atopy and allergic rhinitis in a singapore chinese population. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/f659a63ac296475e9f9aed0ad1c7afc3 |
| work_keys_str_mv |
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