2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

The human 2-oxoglutarate (2OG) oxygenases FIH and AspH are relevant drug targets. Here, the authors show that synthetic and naturally occurring 2OG derivatives can selectively modulate FIH and AspH activities, suggesting that these compounds may serve as a basis to develop 2OG oxygenase-targeting pr...

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Autores principales:	Yu Nakashima, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Christopher J. Schofield
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f65c6124dc4f4697b8a6aadeea9cfc56
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spelling	oai:doaj.org-article:f65c6124dc4f4697b8a6aadeea9cfc562021-11-14T12:34:31Z2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases10.1038/s41467-021-26673-22041-1723https://doaj.org/article/f65c6124dc4f4697b8a6aadeea9cfc562021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26673-2https://doaj.org/toc/2041-1723The human 2-oxoglutarate (2OG) oxygenases FIH and AspH are relevant drug targets. Here, the authors show that synthetic and naturally occurring 2OG derivatives can selectively modulate FIH and AspH activities, suggesting that these compounds may serve as a basis to develop 2OG oxygenase-targeting probes and drugs.Yu NakashimaLennart BrewitzAnthony TumberEidarus SalahChristopher J. SchofieldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Nakashima Lennart Brewitz Anthony Tumber Eidarus Salah Christopher J. Schofield 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
description	The human 2-oxoglutarate (2OG) oxygenases FIH and AspH are relevant drug targets. Here, the authors show that synthetic and naturally occurring 2OG derivatives can selectively modulate FIH and AspH activities, suggesting that these compounds may serve as a basis to develop 2OG oxygenase-targeting probes and drugs.
format	article
author	Yu Nakashima Lennart Brewitz Anthony Tumber Eidarus Salah Christopher J. Schofield
author_facet	Yu Nakashima Lennart Brewitz Anthony Tumber Eidarus Salah Christopher J. Schofield
author_sort	Yu Nakashima
title	2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
title_short	2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
title_full	2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
title_fullStr	2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
title_full_unstemmed	2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
title_sort	2-oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f65c6124dc4f4697b8a6aadeea9cfc56
work_keys_str_mv	AT yunakashima 2oxoglutaratederivativescanselectivelyenhanceorinhibittheactivityofhumanoxygenases AT lennartbrewitz 2oxoglutaratederivativescanselectivelyenhanceorinhibittheactivityofhumanoxygenases AT anthonytumber 2oxoglutaratederivativescanselectivelyenhanceorinhibittheactivityofhumanoxygenases AT eidarussalah 2oxoglutaratederivativescanselectivelyenhanceorinhibittheactivityofhumanoxygenases AT christopherjschofield 2oxoglutaratederivativescanselectivelyenhanceorinhibittheactivityofhumanoxygenases
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2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

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