STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus

STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus

BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the i...

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Main Authors: Yongyao Fu, Jocelyn Wang, Gayathri Panangipalli, Benjamin J. Ulrich, Byunghee Koh, Chengxian Xu, Rakshin Kharwadkar, Xiaona Chu, Yue Wang, Hongyu Gao, Wenting Wu, Jie Sun, Robert S. Tepper, Baohua Zhou, Sarath Chandra Janga, Kai Yang, Mark H. Kaplan
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0
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Summary:BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.

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