STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the i...
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Nature Portfolio
2020
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oai:doaj.org-article:f65e400bd7f5452ca8fba9f15ba2dcc02021-12-02T19:17:00ZSTAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus10.1038/s41467-020-18648-62041-1723https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc02020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18648-6https://doaj.org/toc/2041-1723BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.Yongyao FuJocelyn WangGayathri PanangipalliBenjamin J. UlrichByunghee KohChengxian XuRakshin KharwadkarXiaona ChuYue WangHongyu GaoWenting WuJie SunRobert S. TepperBaohua ZhouSarath Chandra JangaKai YangMark H. KaplanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q Yongyao Fu Jocelyn Wang Gayathri Panangipalli Benjamin J. Ulrich Byunghee Koh Chengxian Xu Rakshin Kharwadkar Xiaona Chu Yue Wang Hongyu Gao Wenting Wu Jie Sun Robert S. Tepper Baohua Zhou Sarath Chandra Janga Kai Yang Mark H. Kaplan STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus |
description |
BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease. |
format |
article |
author |
Yongyao Fu Jocelyn Wang Gayathri Panangipalli Benjamin J. Ulrich Byunghee Koh Chengxian Xu Rakshin Kharwadkar Xiaona Chu Yue Wang Hongyu Gao Wenting Wu Jie Sun Robert S. Tepper Baohua Zhou Sarath Chandra Janga Kai Yang Mark H. Kaplan |
author_facet |
Yongyao Fu Jocelyn Wang Gayathri Panangipalli Benjamin J. Ulrich Byunghee Koh Chengxian Xu Rakshin Kharwadkar Xiaona Chu Yue Wang Hongyu Gao Wenting Wu Jie Sun Robert S. Tepper Baohua Zhou Sarath Chandra Janga Kai Yang Mark H. Kaplan |
author_sort |
Yongyao Fu |
title |
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus |
title_short |
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus |
title_full |
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus |
title_fullStr |
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus |
title_full_unstemmed |
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus |
title_sort |
stat5 promotes accessibility and is required for batf-mediated plasticity at the il9 locus |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0 |
work_keys_str_mv |
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