STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus

BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the i...

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Autores principales: Yongyao Fu, Jocelyn Wang, Gayathri Panangipalli, Benjamin J. Ulrich, Byunghee Koh, Chengxian Xu, Rakshin Kharwadkar, Xiaona Chu, Yue Wang, Hongyu Gao, Wenting Wu, Jie Sun, Robert S. Tepper, Baohua Zhou, Sarath Chandra Janga, Kai Yang, Mark H. Kaplan
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0
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spelling oai:doaj.org-article:f65e400bd7f5452ca8fba9f15ba2dcc02021-12-02T19:17:00ZSTAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus10.1038/s41467-020-18648-62041-1723https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc02020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18648-6https://doaj.org/toc/2041-1723BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.Yongyao FuJocelyn WangGayathri PanangipalliBenjamin J. UlrichByunghee KohChengxian XuRakshin KharwadkarXiaona ChuYue WangHongyu GaoWenting WuJie SunRobert S. TepperBaohua ZhouSarath Chandra JangaKai YangMark H. KaplanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yongyao Fu
Jocelyn Wang
Gayathri Panangipalli
Benjamin J. Ulrich
Byunghee Koh
Chengxian Xu
Rakshin Kharwadkar
Xiaona Chu
Yue Wang
Hongyu Gao
Wenting Wu
Jie Sun
Robert S. Tepper
Baohua Zhou
Sarath Chandra Janga
Kai Yang
Mark H. Kaplan
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
description BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.
format article
author Yongyao Fu
Jocelyn Wang
Gayathri Panangipalli
Benjamin J. Ulrich
Byunghee Koh
Chengxian Xu
Rakshin Kharwadkar
Xiaona Chu
Yue Wang
Hongyu Gao
Wenting Wu
Jie Sun
Robert S. Tepper
Baohua Zhou
Sarath Chandra Janga
Kai Yang
Mark H. Kaplan
author_facet Yongyao Fu
Jocelyn Wang
Gayathri Panangipalli
Benjamin J. Ulrich
Byunghee Koh
Chengxian Xu
Rakshin Kharwadkar
Xiaona Chu
Yue Wang
Hongyu Gao
Wenting Wu
Jie Sun
Robert S. Tepper
Baohua Zhou
Sarath Chandra Janga
Kai Yang
Mark H. Kaplan
author_sort Yongyao Fu
title STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_short STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_full STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_fullStr STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_full_unstemmed STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_sort stat5 promotes accessibility and is required for batf-mediated plasticity at the il9 locus
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0
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