STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus

BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the i...

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Main Authors:	Yongyao Fu, Jocelyn Wang, Gayathri Panangipalli, Benjamin J. Ulrich, Byunghee Koh, Chengxian Xu, Rakshin Kharwadkar, Xiaona Chu, Yue Wang, Hongyu Gao, Wenting Wu, Jie Sun, Robert S. Tepper, Baohua Zhou, Sarath Chandra Janga, Kai Yang, Mark H. Kaplan
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0
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spelling	oai:doaj.org-article:f65e400bd7f5452ca8fba9f15ba2dcc02021-12-02T19:17:00ZSTAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus10.1038/s41467-020-18648-62041-1723https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc02020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18648-6https://doaj.org/toc/2041-1723BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.Yongyao FuJocelyn WangGayathri PanangipalliBenjamin J. UlrichByunghee KohChengxian XuRakshin KharwadkarXiaona ChuYue WangHongyu GaoWenting WuJie SunRobert S. TepperBaohua ZhouSarath Chandra JangaKai YangMark H. KaplanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongyao Fu Jocelyn Wang Gayathri Panangipalli Benjamin J. Ulrich Byunghee Koh Chengxian Xu Rakshin Kharwadkar Xiaona Chu Yue Wang Hongyu Gao Wenting Wu Jie Sun Robert S. Tepper Baohua Zhou Sarath Chandra Janga Kai Yang Mark H. Kaplan STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
description	BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subsets into IL-9 producing cells, thus regulating the immune response to disease.
format	article
author	Yongyao Fu Jocelyn Wang Gayathri Panangipalli Benjamin J. Ulrich Byunghee Koh Chengxian Xu Rakshin Kharwadkar Xiaona Chu Yue Wang Hongyu Gao Wenting Wu Jie Sun Robert S. Tepper Baohua Zhou Sarath Chandra Janga Kai Yang Mark H. Kaplan
author_facet	Yongyao Fu Jocelyn Wang Gayathri Panangipalli Benjamin J. Ulrich Byunghee Koh Chengxian Xu Rakshin Kharwadkar Xiaona Chu Yue Wang Hongyu Gao Wenting Wu Jie Sun Robert S. Tepper Baohua Zhou Sarath Chandra Janga Kai Yang Mark H. Kaplan
author_sort	Yongyao Fu
title	STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_short	STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_full	STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_fullStr	STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_full_unstemmed	STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
title_sort	stat5 promotes accessibility and is required for batf-mediated plasticity at the il9 locus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0
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STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus

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