Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.

Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficult to assess. Mice deleted for beta2-containing nA...

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Autores principales:	Nicolas Maubourguet, Annick Lesne, Jean-Pierre Changeux, Uwe Maskos, Philippe Faure
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f6609c2a1d1f4a59be12b5597be7567e
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spelling	oai:doaj.org-article:f6609c2a1d1f4a59be12b5597be7567e2021-11-25T05:41:57ZBehavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.1553-734X1553-735810.1371/journal.pcbi.1000229https://doaj.org/article/f6609c2a1d1f4a59be12b5597be7567e2008-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19023420/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficult to assess. Mice deleted for beta2-containing nAChRs (beta2-/-) have been shown to be hyperactive in an open-field paradigm, without determining the origin of this hyperactivity. We here develop a quantitative description of mouse behavior in the open field based upon first order Markov and variable length Markov chain analysis focusing on the time-organized sequence that behaviors are composed of. This description reveals that this hyperactivity is the consequence of the absence of specific inactive states or "stops". These stops are associated with a scanning of the environment in wild-type mice (WT), and they affect the way that animals organize their sequence of behaviors when compared with stops without scanning. They characterize a specific "decision moment" that is reduced in beta2-/- mutant mice, suggesting an important role of beta2-nAChRs in the strategy used by animals to explore an environment and collect information in order to organize their behavior. This integrated analysis of the displacement of an animal in a simple environment offers new insights, specifically into the contribution of nAChRs to higher brain functions and more generally into the principles that organize sequences of behaviors in animals.Nicolas MaubourguetAnnick LesneJean-Pierre ChangeuxUwe MaskosPhilippe FaurePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 4, Iss 11, p e1000229 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nicolas Maubourguet Annick Lesne Jean-Pierre Changeux Uwe Maskos Philippe Faure Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
description	Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficult to assess. Mice deleted for beta2-containing nAChRs (beta2-/-) have been shown to be hyperactive in an open-field paradigm, without determining the origin of this hyperactivity. We here develop a quantitative description of mouse behavior in the open field based upon first order Markov and variable length Markov chain analysis focusing on the time-organized sequence that behaviors are composed of. This description reveals that this hyperactivity is the consequence of the absence of specific inactive states or "stops". These stops are associated with a scanning of the environment in wild-type mice (WT), and they affect the way that animals organize their sequence of behaviors when compared with stops without scanning. They characterize a specific "decision moment" that is reduced in beta2-/- mutant mice, suggesting an important role of beta2-nAChRs in the strategy used by animals to explore an environment and collect information in order to organize their behavior. This integrated analysis of the displacement of an animal in a simple environment offers new insights, specifically into the contribution of nAChRs to higher brain functions and more generally into the principles that organize sequences of behaviors in animals.
format	article
author	Nicolas Maubourguet Annick Lesne Jean-Pierre Changeux Uwe Maskos Philippe Faure
author_facet	Nicolas Maubourguet Annick Lesne Jean-Pierre Changeux Uwe Maskos Philippe Faure
author_sort	Nicolas Maubourguet
title	Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
title_short	Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
title_full	Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
title_fullStr	Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
title_full_unstemmed	Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
title_sort	behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/f6609c2a1d1f4a59be12b5597be7567e
work_keys_str_mv	AT nicolasmaubourguet behavioralsequenceanalysisrevealsanovelroleforbeta2nicotinicreceptorsinexploration AT annicklesne behavioralsequenceanalysisrevealsanovelroleforbeta2nicotinicreceptorsinexploration AT jeanpierrechangeux behavioralsequenceanalysisrevealsanovelroleforbeta2nicotinicreceptorsinexploration AT uwemaskos behavioralsequenceanalysisrevealsanovelroleforbeta2nicotinicreceptorsinexploration AT philippefaure behavioralsequenceanalysisrevealsanovelroleforbeta2nicotinicreceptorsinexploration
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Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.

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