Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434

Objectives. Bisphenol A (BPA), as an indispensable plastic additive, has also been proven as an endocrine disruptor associated with adverse health effects including impaired ovarian function and cancer. Due to the restrictions of its usage, several analogs have been employed to replace BPA. Although...

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Autores principales:	Mlynarcikova Alzbeta Bujnakova, Scsukova Sona
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	bisphenol a bisphenol analogs nuclear receptors granulosa cell line cov434 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f660af8034ed4f6da1552af7c8c02b6a
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spelling	oai:doaj.org-article:f660af8034ed4f6da1552af7c8c02b6a2021-12-02T16:41:14ZEffect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV4341336-032910.2478/enr-2020-0031https://doaj.org/article/f660af8034ed4f6da1552af7c8c02b6a2020-10-01T00:00:00Zhttps://doi.org/10.2478/enr-2020-0031https://doaj.org/toc/1336-0329Objectives. Bisphenol A (BPA), as an indispensable plastic additive, has also been proven as an endocrine disruptor associated with adverse health effects including impaired ovarian function and cancer. Due to the restrictions of its usage, several analogs have been employed to replace BPA. Although many studies revealed a harmfulness in the biological effects of BPA analogs, their specific targets remain largely unknown. Nuclear receptors (NRs) may be one of the most important targets of bisphenols. Therefore, in this study, our attention was directed to explore the effect of BPA and its analogs, AF and S, on the mRNA expression of selected NRs involved in the steroidogenic and carcinogenic pathways in the human granulosa cell line COV434. The NRs investigated included: thyroid hormone receptor α (THRA), peroxisome proliferator activating receptor β/δ (PPARD), retinoid X receptor α (RXRA), chicken ovalbumin upstream promoter-transcription factor II (COUPTFII), nuclear receptor-related protein 1 (NURR1), and liver receptor homolog-1 (LRH1).Mlynarcikova Alzbeta BujnakovaScsukova SonaSciendoarticlebisphenol abisphenol analogsnuclear receptorsgranulosa cell line cov434Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 54, Iss 4, Pp 275-283 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	bisphenol a bisphenol analogs nuclear receptors granulosa cell line cov434 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	bisphenol a bisphenol analogs nuclear receptors granulosa cell line cov434 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Mlynarcikova Alzbeta Bujnakova Scsukova Sona Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
description	Objectives. Bisphenol A (BPA), as an indispensable plastic additive, has also been proven as an endocrine disruptor associated with adverse health effects including impaired ovarian function and cancer. Due to the restrictions of its usage, several analogs have been employed to replace BPA. Although many studies revealed a harmfulness in the biological effects of BPA analogs, their specific targets remain largely unknown. Nuclear receptors (NRs) may be one of the most important targets of bisphenols. Therefore, in this study, our attention was directed to explore the effect of BPA and its analogs, AF and S, on the mRNA expression of selected NRs involved in the steroidogenic and carcinogenic pathways in the human granulosa cell line COV434. The NRs investigated included: thyroid hormone receptor α (THRA), peroxisome proliferator activating receptor β/δ (PPARD), retinoid X receptor α (RXRA), chicken ovalbumin upstream promoter-transcription factor II (COUPTFII), nuclear receptor-related protein 1 (NURR1), and liver receptor homolog-1 (LRH1).
format	article
author	Mlynarcikova Alzbeta Bujnakova Scsukova Sona
author_facet	Mlynarcikova Alzbeta Bujnakova Scsukova Sona
author_sort	Mlynarcikova Alzbeta Bujnakova
title	Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
title_short	Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
title_full	Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
title_fullStr	Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
title_full_unstemmed	Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
title_sort	effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line cov434
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/f660af8034ed4f6da1552af7c8c02b6a
work_keys_str_mv	AT mlynarcikovaalzbetabujnakova effectofselectedbisphenolderivativesonnuclearreceptorexpressioninovariancelllinecov434 AT scsukovasona effectofselectedbisphenolderivativesonnuclearreceptorexpressioninovariancelllinecov434
_version_	1718383610043564032

Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434

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