Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test
The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this st...
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Taylor & Francis Group
2020
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oai:doaj.org-article:f662824b874f493ba2afeb9763c7b6ec2021-11-04T15:00:43ZSerology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test2000-868610.1080/20008686.2020.1821513https://doaj.org/article/f662824b874f493ba2afeb9763c7b6ec2020-01-01T00:00:00Zhttp://dx.doi.org/10.1080/20008686.2020.1821513https://doaj.org/toc/2000-8686The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with <2 weeks from disease onset; 85% in non-hospitalized patients with >2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level.Yang De MarinisTorgny SunnerhagenPradeep BompadaAnna BläckbergRuntao YangJoel SvenssonOla EkströmKarl-Fredrik ErikssonOla HanssonLeif GroopIsabel GonçalvesMagnus RasmussenTaylor & Francis Grouparticlecovid-19sars-cov-2serology assessmentantibody testigm and iggdisease severity and durationInfectious and parasitic diseasesRC109-216ENInfection Ecology & Epidemiology, Vol 10, Iss 1 (2020) |
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covid-19 sars-cov-2 serology assessment antibody test igm and igg disease severity and duration Infectious and parasitic diseases RC109-216 |
| spellingShingle |
covid-19 sars-cov-2 serology assessment antibody test igm and igg disease severity and duration Infectious and parasitic diseases RC109-216 Yang De Marinis Torgny Sunnerhagen Pradeep Bompada Anna Bläckberg Runtao Yang Joel Svensson Ola Ekström Karl-Fredrik Eriksson Ola Hansson Leif Groop Isabel Gonçalves Magnus Rasmussen Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test |
| description |
The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with <2 weeks from disease onset; 85% in non-hospitalized patients with >2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level. |
| format |
article |
| author |
Yang De Marinis Torgny Sunnerhagen Pradeep Bompada Anna Bläckberg Runtao Yang Joel Svensson Ola Ekström Karl-Fredrik Eriksson Ola Hansson Leif Groop Isabel Gonçalves Magnus Rasmussen |
| author_facet |
Yang De Marinis Torgny Sunnerhagen Pradeep Bompada Anna Bläckberg Runtao Yang Joel Svensson Ola Ekström Karl-Fredrik Eriksson Ola Hansson Leif Groop Isabel Gonçalves Magnus Rasmussen |
| author_sort |
Yang De Marinis |
| title |
Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test |
| title_short |
Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test |
| title_full |
Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test |
| title_fullStr |
Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test |
| title_full_unstemmed |
Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test |
| title_sort |
serology assessment of antibody response to sars-cov-2 in patients with covid-19 by rapid igm/igg antibody test |
| publisher |
Taylor & Francis Group |
| publishDate |
2020 |
| url |
https://doaj.org/article/f662824b874f493ba2afeb9763c7b6ec |
| work_keys_str_mv |
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