<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity

The fruit fly <i>Drosophila melanogaster</i> has become a valuable model organism in nutritional science, which can be applied to elucidate the physiology and the biological function of nutrients, including trace elements. Importantly, the application of chemically defined diets enables...

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Autores principales:	Katharina Jans, Kai Lüersen, Gerald Rimbach
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lithium boron trace elements fruit fly model organism longevity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f663defcd0ed43e38b91291c27f35234
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spelling	oai:doaj.org-article:f663defcd0ed43e38b91291c27f352342021-11-11T17:10:12Z<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity10.3390/ijms2221117101422-00671661-6596https://doaj.org/article/f663defcd0ed43e38b91291c27f352342021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11710https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The fruit fly <i>Drosophila melanogaster</i> has become a valuable model organism in nutritional science, which can be applied to elucidate the physiology and the biological function of nutrients, including trace elements. Importantly, the application of chemically defined diets enables the supply of trace elements for nutritional studies under highly standardized dietary conditions. Thus, the bioavailability and bioactivity of trace elements can be systematically monitored in <i>D. melanogaster</i>. Numerous studies have already revealed that central aspects of trace element homeostasis are evolutionary conserved among the fruit fly and mammalian species. While there is sufficient evidence of vital functions of boron (B) in plants, there is also evidence regarding its bioactivity in animals and humans. Lithium (Li) is well known for its role in the therapy of bipolar disorder. Furthermore, recent findings suggest beneficial effects of Li regarding neuroprotection as well as healthy ageing and longevity in <i>D. melanogaster</i>. However, no specific essential function in the animal kingdom has been found for either of the two elements so far. Here, we summarize the current knowledge of Li and B bioactivity in <i>D. melanogaster</i> in the context of health and disease prevention.Katharina JansKai LüersenGerald RimbachMDPI AGarticlelithiumborontrace elementsfruit flymodel organismlongevityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11710, p 11710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lithium boron trace elements fruit fly model organism longevity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	lithium boron trace elements fruit fly model organism longevity Biology (General) QH301-705.5 Chemistry QD1-999 Katharina Jans Kai Lüersen Gerald Rimbach <i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity
description	The fruit fly <i>Drosophila melanogaster</i> has become a valuable model organism in nutritional science, which can be applied to elucidate the physiology and the biological function of nutrients, including trace elements. Importantly, the application of chemically defined diets enables the supply of trace elements for nutritional studies under highly standardized dietary conditions. Thus, the bioavailability and bioactivity of trace elements can be systematically monitored in <i>D. melanogaster</i>. Numerous studies have already revealed that central aspects of trace element homeostasis are evolutionary conserved among the fruit fly and mammalian species. While there is sufficient evidence of vital functions of boron (B) in plants, there is also evidence regarding its bioactivity in animals and humans. Lithium (Li) is well known for its role in the therapy of bipolar disorder. Furthermore, recent findings suggest beneficial effects of Li regarding neuroprotection as well as healthy ageing and longevity in <i>D. melanogaster</i>. However, no specific essential function in the animal kingdom has been found for either of the two elements so far. Here, we summarize the current knowledge of Li and B bioactivity in <i>D. melanogaster</i> in the context of health and disease prevention.
format	article
author	Katharina Jans Kai Lüersen Gerald Rimbach
author_facet	Katharina Jans Kai Lüersen Gerald Rimbach
author_sort	Katharina Jans
title	<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity
title_short	<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity
title_full	<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity
title_fullStr	<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity
title_full_unstemmed	<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity
title_sort	<i>drosophila melanogaster</i> as a model organism to study lithium and boron bioactivity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f663defcd0ed43e38b91291c27f35234
work_keys_str_mv	AT katharinajans idrosophilamelanogasteriasamodelorganismtostudylithiumandboronbioactivity AT kailuersen idrosophilamelanogasteriasamodelorganismtostudylithiumandboronbioactivity AT geraldrimbach idrosophilamelanogasteriasamodelorganismtostudylithiumandboronbioactivity
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<i>Drosophila melanogaster</i> as a Model Organism to Study Lithium and Boron Bioactivity

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