Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.

<h4>Objective</h4>Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relations...

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Autores principales:	Jiayu Huang, Qian Zhao, Jiao Li, Jinfeng Meng, Shangbin Li, Weichen Yan, Jie Wang, Changjun Ren
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f66552edb06e42f7a67b6af2332b568b
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spelling	oai:doaj.org-article:f66552edb06e42f7a67b6af2332b568b2021-11-25T05:54:13ZCorrelation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.1932-620310.1371/journal.pone.0251584https://doaj.org/article/f66552edb06e42f7a67b6af2332b568b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251584https://doaj.org/toc/1932-6203<h4>Objective</h4>Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relationship between neonatal hyperbilirubinemia and vitamin D levels.<h4>Method</h4>The China National Knowledge Infrastructure, VIP, Wanfang, Chinese Biology Medicine Disc, PubMed, Web of Science, Cochrane Library, and Embase databases as well as clinical trial registries in China and the United States were searched for relevant studies from inception to September 2020 without restrictions on language, population, or year. The studies was screened by two reviewers independently, the data were extracted, and the risk of bias of the included studies was evaluated using the NOS. A meta-analysis was conducted on the included studies using Stata11 software.<h4>Results</h4>Six case-control studies were included, and the methodological quality of the studies was high (grade A). The studies included 690 newborns; more than 409 were diagnosed with hyperbilirubinemia. The means and standard deviations were calculated. Meta-analysis results showed that neonatal vitamin D levels were 7.1 ng/ml lower among infants with hyperbilirubinemia than among healthy newborn levels (z = 6.95, 95% CI 9.10 ~ 5.09, P < 0.05). Subgroup analysis was conducted based on whether the bilirubin levels were concentrated in the 15 to 20 mg/dl range. Vitamin D level of infants with hyperbilirubinemia (the bilirubin levels were concentrated in the 15 to 20 mg/dl range) was 9.52 ng/ml (Z = 15.55, 95% CI-10.72~-8.32, P<0.05) lower than that of healthy infants. The bilirubin levels in four cases were not concentrated in the 15-20 mg/dl range. The results showed that the vitamin D level of hyperbilirubinemia (The bilirubin levels were not concentrated in the 15-20 mg/dl range) neonates were 5.35 ng/ml lower than that of healthy neonates (Z = 6.43, 95% CI-6.98~-3.72, P<0.05).<h4>Conclusion</h4>Vitamin D levels were observed to be lower in neonates with hyperbilirubinemia as compared to term neonates without hyperbilirubinemia in this study. This can possibly suggest that neonates with lower vitamin D levels are at higher risk for developing hyperbilirubinemia.Jiayu HuangQian ZhaoJiao LiJinfeng MengShangbin LiWeichen YanJie WangChangjun RenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251584 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiayu Huang Qian Zhao Jiao Li Jinfeng Meng Shangbin Li Weichen Yan Jie Wang Changjun Ren Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.
description	<h4>Objective</h4>Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relationship between neonatal hyperbilirubinemia and vitamin D levels.<h4>Method</h4>The China National Knowledge Infrastructure, VIP, Wanfang, Chinese Biology Medicine Disc, PubMed, Web of Science, Cochrane Library, and Embase databases as well as clinical trial registries in China and the United States were searched for relevant studies from inception to September 2020 without restrictions on language, population, or year. The studies was screened by two reviewers independently, the data were extracted, and the risk of bias of the included studies was evaluated using the NOS. A meta-analysis was conducted on the included studies using Stata11 software.<h4>Results</h4>Six case-control studies were included, and the methodological quality of the studies was high (grade A). The studies included 690 newborns; more than 409 were diagnosed with hyperbilirubinemia. The means and standard deviations were calculated. Meta-analysis results showed that neonatal vitamin D levels were 7.1 ng/ml lower among infants with hyperbilirubinemia than among healthy newborn levels (z = 6.95, 95% CI 9.10 ~ 5.09, P < 0.05). Subgroup analysis was conducted based on whether the bilirubin levels were concentrated in the 15 to 20 mg/dl range. Vitamin D level of infants with hyperbilirubinemia (the bilirubin levels were concentrated in the 15 to 20 mg/dl range) was 9.52 ng/ml (Z = 15.55, 95% CI-10.72~-8.32, P<0.05) lower than that of healthy infants. The bilirubin levels in four cases were not concentrated in the 15-20 mg/dl range. The results showed that the vitamin D level of hyperbilirubinemia (The bilirubin levels were not concentrated in the 15-20 mg/dl range) neonates were 5.35 ng/ml lower than that of healthy neonates (Z = 6.43, 95% CI-6.98~-3.72, P<0.05).<h4>Conclusion</h4>Vitamin D levels were observed to be lower in neonates with hyperbilirubinemia as compared to term neonates without hyperbilirubinemia in this study. This can possibly suggest that neonates with lower vitamin D levels are at higher risk for developing hyperbilirubinemia.
format	article
author	Jiayu Huang Qian Zhao Jiao Li Jinfeng Meng Shangbin Li Weichen Yan Jie Wang Changjun Ren
author_facet	Jiayu Huang Qian Zhao Jiao Li Jinfeng Meng Shangbin Li Weichen Yan Jie Wang Changjun Ren
author_sort	Jiayu Huang
title	Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.
title_short	Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.
title_full	Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.
title_fullStr	Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.
title_full_unstemmed	Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.
title_sort	correlation between neonatal hyperbilirubinemia and vitamin d levels: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f66552edb06e42f7a67b6af2332b568b
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Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis.

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