Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.

<h4>Purpose</h4>To analyze ocular biometric parameters alterations of the posterior pole and choroidal abnormalities in patients with neurofibromatosis type 1 (NF1) by adopting multimodal imaging, especially focusing on the role of novel diagnostic devices like swept-source optical coher...

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Autores principales:	Aldo Vagge, Paolo Corazza, Lorenzo Ferro Desideri, Paola Camicione, Giulia Agosto, Roberta Vagge, Calevo Maria Grazia, Adriano Carnevali, Giuseppe Giannaccare, Massimo Nicolò, Carlo Enrico Traverso
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f666cb94ea9443f39c781f802dd24a4d
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spelling	oai:doaj.org-article:f666cb94ea9443f39c781f802dd24a4d2021-11-25T05:54:17ZOcular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.1932-620310.1371/journal.pone.0251098https://doaj.org/article/f666cb94ea9443f39c781f802dd24a4d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251098https://doaj.org/toc/1932-6203<h4>Purpose</h4>To analyze ocular biometric parameters alterations of the posterior pole and choroidal abnormalities in patients with neurofibromatosis type 1 (NF1) by adopting multimodal imaging, especially focusing on the role of novel diagnostic devices like swept-source optical coherence tomography angiography (SS-OCTA).<h4>Methods</h4>In this prospective, case-controlled study, patients with NF1 and age-matched control subjects were quantitatively analyzed by using multimodal imaging. All the subjects underwent confocal scanning laser ophthalmoscopy (SLO), SS-OCT and SS-OCTA examinations.<h4>Results</h4>SS-OCT analysis revealed a lower macular retinal nerve fiber layer (RNFL) thickness in patients with NF1 compared with those with suspected NF1 (95.0±15.9 vs 109.7±11.3 μm; P = 0.001) and control subjects (106.8±14.4 μm, P = 0.003). Retinal thickness was significantly lower in NF1 patients compared to those with suspected NF1 (280.7±23.0 vs 304.2±15.3 μm; P < 0.001) and control subjects (298.7±23.8 μm, P = 0.003). The mean vascular flow area of the SCP was significantly higher in patients with NF1 (42.6±2.2%) and suspected NF1 (43.1±2.5%) compared to control subjects (41.0±2.0%; respectively, P = 0.017 and P = 0.002). In the second choroidal layer, the flow area was significantly lower in patients with NF1 compared to control subjects (45.4±4.8 vs 49.0±4.0%,; P = 0.011).<h4>Conclusions</h4>Retinal thicknesses alterations and choroidal nodules are described as ocular manifestations in patients with NF1. In addition, OCTA could represent an important novel advanced imaging technique, capable of detecting early altered retinal and choroidal vascular flow area in patients with NF1.Aldo VaggePaolo CorazzaLorenzo Ferro DesideriPaola CamicioneGiulia AgostoRoberta VaggeCalevo Maria GraziaAdriano CarnevaliGiuseppe GiannaccareMassimo NicolòCarlo Enrico TraversoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251098 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aldo Vagge Paolo Corazza Lorenzo Ferro Desideri Paola Camicione Giulia Agosto Roberta Vagge Calevo Maria Grazia Adriano Carnevali Giuseppe Giannaccare Massimo Nicolò Carlo Enrico Traverso Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.
description	<h4>Purpose</h4>To analyze ocular biometric parameters alterations of the posterior pole and choroidal abnormalities in patients with neurofibromatosis type 1 (NF1) by adopting multimodal imaging, especially focusing on the role of novel diagnostic devices like swept-source optical coherence tomography angiography (SS-OCTA).<h4>Methods</h4>In this prospective, case-controlled study, patients with NF1 and age-matched control subjects were quantitatively analyzed by using multimodal imaging. All the subjects underwent confocal scanning laser ophthalmoscopy (SLO), SS-OCT and SS-OCTA examinations.<h4>Results</h4>SS-OCT analysis revealed a lower macular retinal nerve fiber layer (RNFL) thickness in patients with NF1 compared with those with suspected NF1 (95.0±15.9 vs 109.7±11.3 μm; P = 0.001) and control subjects (106.8±14.4 μm, P = 0.003). Retinal thickness was significantly lower in NF1 patients compared to those with suspected NF1 (280.7±23.0 vs 304.2±15.3 μm; P < 0.001) and control subjects (298.7±23.8 μm, P = 0.003). The mean vascular flow area of the SCP was significantly higher in patients with NF1 (42.6±2.2%) and suspected NF1 (43.1±2.5%) compared to control subjects (41.0±2.0%; respectively, P = 0.017 and P = 0.002). In the second choroidal layer, the flow area was significantly lower in patients with NF1 compared to control subjects (45.4±4.8 vs 49.0±4.0%,; P = 0.011).<h4>Conclusions</h4>Retinal thicknesses alterations and choroidal nodules are described as ocular manifestations in patients with NF1. In addition, OCTA could represent an important novel advanced imaging technique, capable of detecting early altered retinal and choroidal vascular flow area in patients with NF1.
format	article
author	Aldo Vagge Paolo Corazza Lorenzo Ferro Desideri Paola Camicione Giulia Agosto Roberta Vagge Calevo Maria Grazia Adriano Carnevali Giuseppe Giannaccare Massimo Nicolò Carlo Enrico Traverso
author_facet	Aldo Vagge Paolo Corazza Lorenzo Ferro Desideri Paola Camicione Giulia Agosto Roberta Vagge Calevo Maria Grazia Adriano Carnevali Giuseppe Giannaccare Massimo Nicolò Carlo Enrico Traverso
author_sort	Aldo Vagge
title	Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.
title_short	Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.
title_full	Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.
title_fullStr	Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.
title_full_unstemmed	Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.
title_sort	ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by oct-a.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f666cb94ea9443f39c781f802dd24a4d
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Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A.

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