Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia

Background and Objective: Midazolam is the only drug of benzodiazepine category that because of its fast effect and least cardiovascular complications is used for induction and maintenance of anesthesia. Also, halothane is the most common drug for maintenance of anesthesia with some complications th...

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Autores principales:	F Naziri, E Alijan Pour, AR Firooz Jahi, M Jalalian
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2002
Materias:	maintenance of anesthesia midazolam halothane blood pressure heart rate Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f666db9ab90841db80bde4334e07f04f
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spelling	oai:doaj.org-article:f666db9ab90841db80bde4334e07f04f2021-11-10T09:19:40ZEffect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia1561-41072251-7170https://doaj.org/article/f666db9ab90841db80bde4334e07f04f2002-07-01T00:00:00Zhttp://jbums.org/article-1-2815-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Midazolam is the only drug of benzodiazepine category that because of its fast effect and least cardiovascular complications is used for induction and maintenance of anesthesia. Also, halothane is the most common drug for maintenance of anesthesia with some complications that causes a tendency to use IV anesthesia. This study was done to determine the effect of midazolam and halothane on hemodynamic changes in maintenance of anesthesia. Methods: This study was conducted on 100 cases (16-60 years old) in ASA class I (American society of anesthesiologists). They were randomly divided into two groups (Each group 50 persons). Subjects in both groups were administered with premedication and induction of anesthesia with an equal dose according to their weight and then tracheal intubation was done. For the maintenance of anesthesia, control and case group received halothane (0.5-1%) and midazolam (1 µg/kg/min), respectively and both groups received N2O and oxygen (50%) equally. Heart rate, systolic and diastolic blood pressure were measured and recorded after premedication, 1 min after induction and every 10 min during 90 minutes and then data was compared. Findings: According to the obtained results, the changes of heart rate and systolic and diastolic blood pressure in midazolam group was less than halothane group and there was not a statistically significant difference. The range of systolic and diastolic blood pressure changes in midazolam group in comparison to halothane group was less and it was statistically considered significant (P<0.05). Emergence from general anesthesia in midazolam group was less than halothane that this difference was meaningful (P=0.01). Conclusion: Hemodynamic changes in maintenance of anesthesia with infusion of midazolam in comparison to halothane were similar or less. If it is necessary, continuous infusion of midazolam can be used instead of halothane with regard to its some complications.F NaziriE Alijan PourAR Firooz JahiM JalalianBabol University of Medical Sciencesarticlemaintenance of anesthesiamidazolamhalothaneblood pressureheart rateMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 4, Iss 3, Pp 7-11 (2002)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	maintenance of anesthesia midazolam halothane blood pressure heart rate Medicine R Medicine (General) R5-920
spellingShingle	maintenance of anesthesia midazolam halothane blood pressure heart rate Medicine R Medicine (General) R5-920 F Naziri E Alijan Pour AR Firooz Jahi M Jalalian Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia
description	Background and Objective: Midazolam is the only drug of benzodiazepine category that because of its fast effect and least cardiovascular complications is used for induction and maintenance of anesthesia. Also, halothane is the most common drug for maintenance of anesthesia with some complications that causes a tendency to use IV anesthesia. This study was done to determine the effect of midazolam and halothane on hemodynamic changes in maintenance of anesthesia. Methods: This study was conducted on 100 cases (16-60 years old) in ASA class I (American society of anesthesiologists). They were randomly divided into two groups (Each group 50 persons). Subjects in both groups were administered with premedication and induction of anesthesia with an equal dose according to their weight and then tracheal intubation was done. For the maintenance of anesthesia, control and case group received halothane (0.5-1%) and midazolam (1 µg/kg/min), respectively and both groups received N2O and oxygen (50%) equally. Heart rate, systolic and diastolic blood pressure were measured and recorded after premedication, 1 min after induction and every 10 min during 90 minutes and then data was compared. Findings: According to the obtained results, the changes of heart rate and systolic and diastolic blood pressure in midazolam group was less than halothane group and there was not a statistically significant difference. The range of systolic and diastolic blood pressure changes in midazolam group in comparison to halothane group was less and it was statistically considered significant (P<0.05). Emergence from general anesthesia in midazolam group was less than halothane that this difference was meaningful (P=0.01). Conclusion: Hemodynamic changes in maintenance of anesthesia with infusion of midazolam in comparison to halothane were similar or less. If it is necessary, continuous infusion of midazolam can be used instead of halothane with regard to its some complications.
format	article
author	F Naziri E Alijan Pour AR Firooz Jahi M Jalalian
author_facet	F Naziri E Alijan Pour AR Firooz Jahi M Jalalian
author_sort	F Naziri
title	Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia
title_short	Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia
title_full	Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia
title_fullStr	Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia
title_full_unstemmed	Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia
title_sort	effect of midazolam and halothane on hemodynamic changes in maintenance of anesthesia
publisher	Babol University of Medical Sciences
publishDate	2002
url	https://doaj.org/article/f666db9ab90841db80bde4334e07f04f
work_keys_str_mv	AT fnaziri effectofmidazolamandhalothaneonhemodynamicchangesinmaintenanceofanesthesia AT ealijanpour effectofmidazolamandhalothaneonhemodynamicchangesinmaintenanceofanesthesia AT arfiroozjahi effectofmidazolamandhalothaneonhemodynamicchangesinmaintenanceofanesthesia AT mjalalian effectofmidazolamandhalothaneonhemodynamicchangesinmaintenanceofanesthesia
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Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia

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