Highly variable microbiota development in the chicken gastrointestinal tract.

Studies investigating the role that complex microbiotas associated with animals and humans play in health and wellbeing have been greatly facilitated by advances in DNA sequencing technology. Due to the still relatively high sequencing costs and the expense of establishing and running animal trials...

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Autores principales:	Dragana Stanley, Mark S Geier, Robert J Hughes, Stuart E Denman, Robert J Moore
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6672723c5ac4a6795a0c62b791cc627
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spelling	oai:doaj.org-article:f6672723c5ac4a6795a0c62b791cc6272021-11-18T08:39:21ZHighly variable microbiota development in the chicken gastrointestinal tract.1932-620310.1371/journal.pone.0084290https://doaj.org/article/f6672723c5ac4a6795a0c62b791cc6272013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24391931/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Studies investigating the role that complex microbiotas associated with animals and humans play in health and wellbeing have been greatly facilitated by advances in DNA sequencing technology. Due to the still relatively high sequencing costs and the expense of establishing and running animal trials and collecting clinical samples, most of the studies reported in the literature are limited to a single trial and relatively small numbers of samples. Results from different laboratories, investigating similar trials and samples, have often produced quite different pictures of microbiota composition. This study investigated batch to batch variations in chicken cecal microbiota across three similar trials, represented by individually analysed samples from 207 birds. Very different microbiota profiles were found across the three flocks. The flocks also differed in the efficiency of nutrient use as indicated by feed conversion ratios. In addition, large variations in the microbiota of birds within a single trial were noted. It is postulated that the large variability in microbiota composition is due, at least in part, to the lack of colonisation of the chicks by maternally derived bacteria. The high hygiene levels maintained in modern commercial hatcheries, although effective in reducing the burden of specific diseases, may have the undesirable effect of causing highly variable bacterial colonization of the gut. Studies in humans and other animals have previously demonstrated large variations in microbiota composition when comparing individuals from different populations and from different environments but this study shows that even under carefully controlled conditions large variations in microbiota composition still occur.Dragana StanleyMark S GeierRobert J HughesStuart E DenmanRobert J MoorePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e84290 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dragana Stanley Mark S Geier Robert J Hughes Stuart E Denman Robert J Moore Highly variable microbiota development in the chicken gastrointestinal tract.
description	Studies investigating the role that complex microbiotas associated with animals and humans play in health and wellbeing have been greatly facilitated by advances in DNA sequencing technology. Due to the still relatively high sequencing costs and the expense of establishing and running animal trials and collecting clinical samples, most of the studies reported in the literature are limited to a single trial and relatively small numbers of samples. Results from different laboratories, investigating similar trials and samples, have often produced quite different pictures of microbiota composition. This study investigated batch to batch variations in chicken cecal microbiota across three similar trials, represented by individually analysed samples from 207 birds. Very different microbiota profiles were found across the three flocks. The flocks also differed in the efficiency of nutrient use as indicated by feed conversion ratios. In addition, large variations in the microbiota of birds within a single trial were noted. It is postulated that the large variability in microbiota composition is due, at least in part, to the lack of colonisation of the chicks by maternally derived bacteria. The high hygiene levels maintained in modern commercial hatcheries, although effective in reducing the burden of specific diseases, may have the undesirable effect of causing highly variable bacterial colonization of the gut. Studies in humans and other animals have previously demonstrated large variations in microbiota composition when comparing individuals from different populations and from different environments but this study shows that even under carefully controlled conditions large variations in microbiota composition still occur.
format	article
author	Dragana Stanley Mark S Geier Robert J Hughes Stuart E Denman Robert J Moore
author_facet	Dragana Stanley Mark S Geier Robert J Hughes Stuart E Denman Robert J Moore
author_sort	Dragana Stanley
title	Highly variable microbiota development in the chicken gastrointestinal tract.
title_short	Highly variable microbiota development in the chicken gastrointestinal tract.
title_full	Highly variable microbiota development in the chicken gastrointestinal tract.
title_fullStr	Highly variable microbiota development in the chicken gastrointestinal tract.
title_full_unstemmed	Highly variable microbiota development in the chicken gastrointestinal tract.
title_sort	highly variable microbiota development in the chicken gastrointestinal tract.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f6672723c5ac4a6795a0c62b791cc627
work_keys_str_mv	AT draganastanley highlyvariablemicrobiotadevelopmentinthechickengastrointestinaltract AT marksgeier highlyvariablemicrobiotadevelopmentinthechickengastrointestinaltract AT robertjhughes highlyvariablemicrobiotadevelopmentinthechickengastrointestinaltract AT stuartedenman highlyvariablemicrobiotadevelopmentinthechickengastrointestinaltract AT robertjmoore highlyvariablemicrobiotadevelopmentinthechickengastrointestinaltract
_version_	1718421538227617792

Highly variable microbiota development in the chicken gastrointestinal tract.

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