Rotational-invariant speckle-scanning ultrasonography through thick bones

Abstract Ultrasonography is a major medical imaging technique that has been broadly applied in many disease diagnoses. However, due to strong aberration and scattering in the human skull, high-resolution transcranial ultrasonic imaging remains a grand challenge. Here, we explore the rotational-invar...

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Autores principales:	Siyi Liang, Lidai Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f66740346fb44260bf396b85f3a030d5
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id	oai:doaj.org-article:f66740346fb44260bf396b85f3a030d5
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spelling	oai:doaj.org-article:f66740346fb44260bf396b85f3a030d52021-12-02T15:22:57ZRotational-invariant speckle-scanning ultrasonography through thick bones10.1038/s41598-021-93488-y2045-2322https://doaj.org/article/f66740346fb44260bf396b85f3a030d52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93488-yhttps://doaj.org/toc/2045-2322Abstract Ultrasonography is a major medical imaging technique that has been broadly applied in many disease diagnoses. However, due to strong aberration and scattering in the human skull, high-resolution transcranial ultrasonic imaging remains a grand challenge. Here, we explore the rotational-invariant property of ultrasonic speckle and develop high-resolution speckle-scanning ultrasonography to image sub-millimeter-sized features through thick bones. We experimentally validate the rotational invariance of ultrasonic speckle. Based on this property, we scan a random ultrasonic speckle pattern across an object sandwiched between two thick bones so that the object features can be encoded to the ultrasonic waves. After receiving the transmitted ultrasonic waves, we reconstruct the image of the object using an iterative phase retrieval algorithm. We successfully demonstrate imaging of hole and tube features sized as fine as several hundreds of microns between two 0.5 ~ 1-cm-thick bones. With 2.5-MHz excitation and the third-harmonic detection, we measure the spatial resolution as 352 µm. Rotational-invariant speckle-scanning ultrasonography offers a new approach to image through thick bones and paves an avenue towards high-resolution ultrasonic imaging of the human brain.Siyi LiangLidai WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siyi Liang Lidai Wang Rotational-invariant speckle-scanning ultrasonography through thick bones
description	Abstract Ultrasonography is a major medical imaging technique that has been broadly applied in many disease diagnoses. However, due to strong aberration and scattering in the human skull, high-resolution transcranial ultrasonic imaging remains a grand challenge. Here, we explore the rotational-invariant property of ultrasonic speckle and develop high-resolution speckle-scanning ultrasonography to image sub-millimeter-sized features through thick bones. We experimentally validate the rotational invariance of ultrasonic speckle. Based on this property, we scan a random ultrasonic speckle pattern across an object sandwiched between two thick bones so that the object features can be encoded to the ultrasonic waves. After receiving the transmitted ultrasonic waves, we reconstruct the image of the object using an iterative phase retrieval algorithm. We successfully demonstrate imaging of hole and tube features sized as fine as several hundreds of microns between two 0.5 ~ 1-cm-thick bones. With 2.5-MHz excitation and the third-harmonic detection, we measure the spatial resolution as 352 µm. Rotational-invariant speckle-scanning ultrasonography offers a new approach to image through thick bones and paves an avenue towards high-resolution ultrasonic imaging of the human brain.
format	article
author	Siyi Liang Lidai Wang
author_facet	Siyi Liang Lidai Wang
author_sort	Siyi Liang
title	Rotational-invariant speckle-scanning ultrasonography through thick bones
title_short	Rotational-invariant speckle-scanning ultrasonography through thick bones
title_full	Rotational-invariant speckle-scanning ultrasonography through thick bones
title_fullStr	Rotational-invariant speckle-scanning ultrasonography through thick bones
title_full_unstemmed	Rotational-invariant speckle-scanning ultrasonography through thick bones
title_sort	rotational-invariant speckle-scanning ultrasonography through thick bones
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f66740346fb44260bf396b85f3a030d5
work_keys_str_mv	AT siyiliang rotationalinvariantspecklescanningultrasonographythroughthickbones AT lidaiwang rotationalinvariantspecklescanningultrasonographythroughthickbones
_version_	1718387406808285184

Rotational-invariant speckle-scanning ultrasonography through thick bones

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