INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES

Abstract. Treatment of chronic wounds is a difficult problem of contemporary surgery. An opportunity of curing these wounds by means of cytokines, such as interleukin-1 (IL-1), is an issue of great interest. A clinical trial of IL-1β was performed in the patients with chronic wounds of different ori...

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Autores principales:	E. A. Varyushina, E. A. Moskalenko, T. P. Lebedeva, A. N. Bubnov, A. S. Simbirtsev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	il-1β chronic wounds trophic ulcers diabetes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f667d14126814558950170862f15aa8d
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spelling	oai:doaj.org-article:f667d14126814558950170862f15aa8d2021-11-18T08:03:39ZINTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES1563-06252313-741X10.15789/1563-0625-2008-4-5-439-448https://doaj.org/article/f667d14126814558950170862f15aa8d2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/210https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Treatment of chronic wounds is a difficult problem of contemporary surgery. An opportunity of curing these wounds by means of cytokines, such as interleukin-1 (IL-1), is an issue of great interest. A clinical trial of IL-1β was performed in the patients with chronic wounds of different origin. Recombinant human IL-1β was applied in six ointment compositions containing active drug (0.05 to 5000 ng/ml) using a hydrophobic vehicle. The preparations were used to treat non-healing wounds and trophic ulcers in patients with diseases of lower extremities complicated by venous insufficiency or diabetes type I and II. Clinical examinations, wound area measurements and cytological analysis of wound smears were performed before starting the treatment and in the course of therapy. Clinical results for the wound lesions (2nd and 3rd phases) have demonstrated high efficacy of ointments containing IL-1β at 0.5 to 5000 ng/ml. The most efficient concentration was determined as 50 ng IL-1β in 1 ml of ointment. IL-1β treatment caused clinical improvement of wound healing in 90% of the patients, including those with diabetes. IL-1β application during 2nd and 3rd phases of wound process showed good correlations with cytological changes in wound cell smears. When using IL-1β-containing ointments, the terms of granulation and epithelisation terms were reduced, along with 1.5-fold increase in average healing rates, as compared to conventional treatment with Solcoseril and Vulnusan. Mechanisms of IL-1β action were similar for the patients with wounds of different origin. Application of IL-1β-containing requires daily changes of wound dressings with the ointment. What to complications, local allergic reactions were detected only in 1.9% of cases. To summarize, the results of our study provide an evidence that IL-1β-containing ointment is a useful drug for effective treatment of non-healing wounds and trophic ulcers in patients. (Med. Immunol., vol. 10, N 4-5, pp 439-448).E. A. VaryushinaE. A. MoskalenkoT. P. LebedevaA. N. BubnovA. S. SimbirtsevSPb RAACIarticleil-1βchronic woundstrophic ulcersdiabetesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 439-448 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	il-1β chronic wounds trophic ulcers diabetes Immunologic diseases. Allergy RC581-607
spellingShingle	il-1β chronic wounds trophic ulcers diabetes Immunologic diseases. Allergy RC581-607 E. A. Varyushina E. A. Moskalenko T. P. Lebedeva A. N. Bubnov A. S. Simbirtsev INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES
description	Abstract. Treatment of chronic wounds is a difficult problem of contemporary surgery. An opportunity of curing these wounds by means of cytokines, such as interleukin-1 (IL-1), is an issue of great interest. A clinical trial of IL-1β was performed in the patients with chronic wounds of different origin. Recombinant human IL-1β was applied in six ointment compositions containing active drug (0.05 to 5000 ng/ml) using a hydrophobic vehicle. The preparations were used to treat non-healing wounds and trophic ulcers in patients with diseases of lower extremities complicated by venous insufficiency or diabetes type I and II. Clinical examinations, wound area measurements and cytological analysis of wound smears were performed before starting the treatment and in the course of therapy. Clinical results for the wound lesions (2nd and 3rd phases) have demonstrated high efficacy of ointments containing IL-1β at 0.5 to 5000 ng/ml. The most efficient concentration was determined as 50 ng IL-1β in 1 ml of ointment. IL-1β treatment caused clinical improvement of wound healing in 90% of the patients, including those with diabetes. IL-1β application during 2nd and 3rd phases of wound process showed good correlations with cytological changes in wound cell smears. When using IL-1β-containing ointments, the terms of granulation and epithelisation terms were reduced, along with 1.5-fold increase in average healing rates, as compared to conventional treatment with Solcoseril and Vulnusan. Mechanisms of IL-1β action were similar for the patients with wounds of different origin. Application of IL-1β-containing requires daily changes of wound dressings with the ointment. What to complications, local allergic reactions were detected only in 1.9% of cases. To summarize, the results of our study provide an evidence that IL-1β-containing ointment is a useful drug for effective treatment of non-healing wounds and trophic ulcers in patients. (Med. Immunol., vol. 10, N 4-5, pp 439-448).
format	article
author	E. A. Varyushina E. A. Moskalenko T. P. Lebedeva A. N. Bubnov A. S. Simbirtsev
author_facet	E. A. Varyushina E. A. Moskalenko T. P. Lebedeva A. N. Bubnov A. S. Simbirtsev
author_sort	E. A. Varyushina
title	INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES
title_short	INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES
title_full	INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES
title_fullStr	INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES
title_full_unstemmed	INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES
title_sort	interleukin-1β application for local treatment of purulent and necrotic lesions of lower extremities
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f667d14126814558950170862f15aa8d
work_keys_str_mv	AT eavaryushina interleukin1bapplicationforlocaltreatmentofpurulentandnecroticlesionsoflowerextremities AT eamoskalenko interleukin1bapplicationforlocaltreatmentofpurulentandnecroticlesionsoflowerextremities AT tplebedeva interleukin1bapplicationforlocaltreatmentofpurulentandnecroticlesionsoflowerextremities AT anbubnov interleukin1bapplicationforlocaltreatmentofpurulentandnecroticlesionsoflowerextremities AT assimbirtsev interleukin1bapplicationforlocaltreatmentofpurulentandnecroticlesionsoflowerextremities
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INTERLEUKIN-1β APPLICATION FOR LOCAL TREATMENT OF PURULENT AND NECROTIC LESIONS OF LOWER EXTREMITIES

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