Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed

Abstract Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its shortest format, treatment of TB requires six months of multidrug therapy with a mixture of broad spectrum and mycobacterial specific an...

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Autores principales:	Matthew F. Wipperman, Daniel W. Fitzgerald, Marc Antoine Jean Juste, Ying Taur, Sivaranjani Namasivayam, Alan Sher, James M. Bean, Vanni Bucci, Michael S. Glickman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f66b6683dbd843a1b6958015744bf3a6
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spelling	oai:doaj.org-article:f66b6683dbd843a1b6958015744bf3a62021-12-02T15:05:38ZAntibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed10.1038/s41598-017-10346-62045-2322https://doaj.org/article/f66b6683dbd843a1b6958015744bf3a62017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10346-6https://doaj.org/toc/2045-2322Abstract Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its shortest format, treatment of TB requires six months of multidrug therapy with a mixture of broad spectrum and mycobacterial specific antibiotics, and treatment of multidrug resistant TB is longer. The widespread use of this regimen makes this one of the largest exposures of humans to antimicrobials, yet the effects of TB treatment on intestinal microbiome composition and long-term stability are unknown. We compared the microbiome composition, assessed by both 16S rDNA and metagenomic DNA sequencing, of TB cases during antimycobacterial treatment and following cure by 6 months of antibiotics. TB treatment does not perturb overall diversity, but nonetheless dramatically depletes multiple immunologically significant commensal bacteria. The microbiomic perturbation of TB therapy can persist for at least 1.2 years, indicating that the effects of TB treatment are long lasting. These results demonstrate that TB treatment has dramatic effects on the intestinal microbiome and highlight unexpected durable consequences of treatment for the world’s most common infection on human ecology.Matthew F. WippermanDaniel W. FitzgeraldMarc Antoine Jean JusteYing TaurSivaranjani NamasivayamAlan SherJames M. BeanVanni BucciMichael S. GlickmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew F. Wipperman Daniel W. Fitzgerald Marc Antoine Jean Juste Ying Taur Sivaranjani Namasivayam Alan Sher James M. Bean Vanni Bucci Michael S. Glickman Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
description	Abstract Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world’s population and causes substantial mortality worldwide. In its shortest format, treatment of TB requires six months of multidrug therapy with a mixture of broad spectrum and mycobacterial specific antibiotics, and treatment of multidrug resistant TB is longer. The widespread use of this regimen makes this one of the largest exposures of humans to antimicrobials, yet the effects of TB treatment on intestinal microbiome composition and long-term stability are unknown. We compared the microbiome composition, assessed by both 16S rDNA and metagenomic DNA sequencing, of TB cases during antimycobacterial treatment and following cure by 6 months of antibiotics. TB treatment does not perturb overall diversity, but nonetheless dramatically depletes multiple immunologically significant commensal bacteria. The microbiomic perturbation of TB therapy can persist for at least 1.2 years, indicating that the effects of TB treatment are long lasting. These results demonstrate that TB treatment has dramatic effects on the intestinal microbiome and highlight unexpected durable consequences of treatment for the world’s most common infection on human ecology.
format	article
author	Matthew F. Wipperman Daniel W. Fitzgerald Marc Antoine Jean Juste Ying Taur Sivaranjani Namasivayam Alan Sher James M. Bean Vanni Bucci Michael S. Glickman
author_facet	Matthew F. Wipperman Daniel W. Fitzgerald Marc Antoine Jean Juste Ying Taur Sivaranjani Namasivayam Alan Sher James M. Bean Vanni Bucci Michael S. Glickman
author_sort	Matthew F. Wipperman
title	Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
title_short	Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
title_full	Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
title_fullStr	Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
title_full_unstemmed	Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
title_sort	antibiotic treatment for tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f66b6683dbd843a1b6958015744bf3a6
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Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed

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