Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs

Abstract Commercial pigs are frequently exposed to tail mutilations in the form of preventive husbandry procedures (tail docking) or as a result of abnormal behaviour (tail biting). Although tissue and nerve injuries are well-described causes of pain hypersensitivity in humans and in rodent animal m...

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Autores principales:	Pierpaolo Di Giminiani, Sandra A. Edwards, Emma M. Malcolm, Matthew C. Leach, Mette S. Herskin, Dale A. Sandercock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f66d0c831d4047479502dc9919aad7c6
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spelling	oai:doaj.org-article:f66d0c831d4047479502dc9919aad7c62021-12-02T16:06:07ZCharacterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs10.1038/s41598-017-05404-y2045-2322https://doaj.org/article/f66d0c831d4047479502dc9919aad7c62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05404-yhttps://doaj.org/toc/2045-2322Abstract Commercial pigs are frequently exposed to tail mutilations in the form of preventive husbandry procedures (tail docking) or as a result of abnormal behaviour (tail biting). Although tissue and nerve injuries are well-described causes of pain hypersensitivity in humans and in rodent animal models, there is no information on the changes in local pain sensitivity induced by tail injuries in pigs. To determine the temporal profile of sensitisation, pigs were exposed to surgical tail resections and mechanical nociceptive thresholds (MNT) were measured in the acute (one week post-operatively) and in the long-term (either eight or sixteen weeks post-surgery) phase of recovery. The influence of the degree of amputation on MNTs was also evaluated by comparing three different tail-resection treatments (intact, ‘short tail’, ‘long tail’). A significant reduction in MNTs one week following surgery suggests the occurrence of acute sensitisation. Long-term hypersensitivity was also observed in tail-resected pigs at either two or four months following surgery. Tail amputation in pigs appears to evoke acute and sustained changes in peripheral mechanical sensitivity, which resemble features of neuropathic pain reported in humans and other species and provides new information on implications for the welfare of animals subjected to this type of injury.Pierpaolo Di GiminianiSandra A. EdwardsEmma M. MalcolmMatthew C. LeachMette S. HerskinDale A. SandercockNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pierpaolo Di Giminiani Sandra A. Edwards Emma M. Malcolm Matthew C. Leach Mette S. Herskin Dale A. Sandercock Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs
description	Abstract Commercial pigs are frequently exposed to tail mutilations in the form of preventive husbandry procedures (tail docking) or as a result of abnormal behaviour (tail biting). Although tissue and nerve injuries are well-described causes of pain hypersensitivity in humans and in rodent animal models, there is no information on the changes in local pain sensitivity induced by tail injuries in pigs. To determine the temporal profile of sensitisation, pigs were exposed to surgical tail resections and mechanical nociceptive thresholds (MNT) were measured in the acute (one week post-operatively) and in the long-term (either eight or sixteen weeks post-surgery) phase of recovery. The influence of the degree of amputation on MNTs was also evaluated by comparing three different tail-resection treatments (intact, ‘short tail’, ‘long tail’). A significant reduction in MNTs one week following surgery suggests the occurrence of acute sensitisation. Long-term hypersensitivity was also observed in tail-resected pigs at either two or four months following surgery. Tail amputation in pigs appears to evoke acute and sustained changes in peripheral mechanical sensitivity, which resemble features of neuropathic pain reported in humans and other species and provides new information on implications for the welfare of animals subjected to this type of injury.
format	article
author	Pierpaolo Di Giminiani Sandra A. Edwards Emma M. Malcolm Matthew C. Leach Mette S. Herskin Dale A. Sandercock
author_facet	Pierpaolo Di Giminiani Sandra A. Edwards Emma M. Malcolm Matthew C. Leach Mette S. Herskin Dale A. Sandercock
author_sort	Pierpaolo Di Giminiani
title	Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs
title_short	Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs
title_full	Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs
title_fullStr	Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs
title_full_unstemmed	Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs
title_sort	characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f66d0c831d4047479502dc9919aad7c6
work_keys_str_mv	AT pierpaolodigiminiani characterizationofshortandlongtermmechanicalsensitisationfollowingsurgicaltailamputationinpigs AT sandraaedwards characterizationofshortandlongtermmechanicalsensitisationfollowingsurgicaltailamputationinpigs AT emmammalcolm characterizationofshortandlongtermmechanicalsensitisationfollowingsurgicaltailamputationinpigs AT matthewcleach characterizationofshortandlongtermmechanicalsensitisationfollowingsurgicaltailamputationinpigs AT mettesherskin characterizationofshortandlongtermmechanicalsensitisationfollowingsurgicaltailamputationinpigs AT daleasandercock characterizationofshortandlongtermmechanicalsensitisationfollowingsurgicaltailamputationinpigs
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Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs

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