The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy

The purpose of this study was to assess whether metabolomics, associated with echocardiography, was able to highlight pathophysiological differences between obstructive (OHCM) or non-obstructive (NOHCM) hypertrophic cardiomyopathy. Thirty-one HCM patients underwent standard and advanced echocardiogr...

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Autores principales:	Martino Deidda, Antonio Noto, Daniele Pasqualucci, Claudia Fattuoni, Luigi Barberini, Cristina Piras, Pier Paolo Bassareo, Maurizio Porcu, Giuseppe Mercuro, Christian Cadeddu Dessalvi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metabolomics global longitudinal strain 3D echocardiography obstructive hypertrophic cardiomyopathy non-obstructive hypertrophic cardiomyopathy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f66d553cb4904707a448518ed320d59a
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spelling	oai:doaj.org-article:f66d553cb4904707a448518ed320d59a2021-11-25T18:20:55ZThe Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy10.3390/metabo111107872218-1989https://doaj.org/article/f66d553cb4904707a448518ed320d59a2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/787https://doaj.org/toc/2218-1989The purpose of this study was to assess whether metabolomics, associated with echocardiography, was able to highlight pathophysiological differences between obstructive (OHCM) or non-obstructive (NOHCM) hypertrophic cardiomyopathy. Thirty-one HCM patients underwent standard and advanced echocardiography; a plasma sample was collected for metabolomic analysis. Results. Patients with OHCM compared with subjects with NOHCM had higher values of 2DLVEF (66.5 ± 3.3% vs. 60.6 ± 1.8%, <i>p</i> < 0.01), S wave (7.6 ± 1.1 vs. 6.3 ± 0.7 cm/s, <i>p</i> < 0.01) and 3D global longitudinal strain (17.2 ± 4.2%, vs. 13.4 ± 1.3%, <i>p</i> < 0.05). A 2-group PLS-Discriminant Analysis was performed to verify whether the two HCM groups differed also based on the metabolic fingerprint. A clear clustering was shown (ANOVA <i>p</i> = 0.014). The most discriminating metabolites resulted as follows: in the NOHCM Group, there were higher levels of threitol, aminomalonic acid, and sucrose, while the OHCM Group presented higher levels of amino acids, in particular those branched chains, of intermediates of glycolysis (lactate) and the Krebs cycle (fumarate, succinate, citrate), of fatty acids (arachidonic acid, palmitoleic acid), of ketone bodies (2-OH-butyrate). Our data point out a different systolic function related to a specific metabolic activity in the two HCM phenotypic forms, with specific metabolites associated with better contractility in OHCM.Martino DeiddaAntonio NotoDaniele PasqualucciClaudia FattuoniLuigi BarberiniCristina PirasPier Paolo BassareoMaurizio PorcuGiuseppe MercuroChristian Cadeddu DessalviMDPI AGarticlemetabolomicsglobal longitudinal strain3D echocardiographyobstructive hypertrophic cardiomyopathynon-obstructive hypertrophic cardiomyopathyMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 787, p 787 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics global longitudinal strain 3D echocardiography obstructive hypertrophic cardiomyopathy non-obstructive hypertrophic cardiomyopathy Microbiology QR1-502
spellingShingle	metabolomics global longitudinal strain 3D echocardiography obstructive hypertrophic cardiomyopathy non-obstructive hypertrophic cardiomyopathy Microbiology QR1-502 Martino Deidda Antonio Noto Daniele Pasqualucci Claudia Fattuoni Luigi Barberini Cristina Piras Pier Paolo Bassareo Maurizio Porcu Giuseppe Mercuro Christian Cadeddu Dessalvi The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy
description	The purpose of this study was to assess whether metabolomics, associated with echocardiography, was able to highlight pathophysiological differences between obstructive (OHCM) or non-obstructive (NOHCM) hypertrophic cardiomyopathy. Thirty-one HCM patients underwent standard and advanced echocardiography; a plasma sample was collected for metabolomic analysis. Results. Patients with OHCM compared with subjects with NOHCM had higher values of 2DLVEF (66.5 ± 3.3% vs. 60.6 ± 1.8%, <i>p</i> < 0.01), S wave (7.6 ± 1.1 vs. 6.3 ± 0.7 cm/s, <i>p</i> < 0.01) and 3D global longitudinal strain (17.2 ± 4.2%, vs. 13.4 ± 1.3%, <i>p</i> < 0.05). A 2-group PLS-Discriminant Analysis was performed to verify whether the two HCM groups differed also based on the metabolic fingerprint. A clear clustering was shown (ANOVA <i>p</i> = 0.014). The most discriminating metabolites resulted as follows: in the NOHCM Group, there were higher levels of threitol, aminomalonic acid, and sucrose, while the OHCM Group presented higher levels of amino acids, in particular those branched chains, of intermediates of glycolysis (lactate) and the Krebs cycle (fumarate, succinate, citrate), of fatty acids (arachidonic acid, palmitoleic acid), of ketone bodies (2-OH-butyrate). Our data point out a different systolic function related to a specific metabolic activity in the two HCM phenotypic forms, with specific metabolites associated with better contractility in OHCM.
format	article
author	Martino Deidda Antonio Noto Daniele Pasqualucci Claudia Fattuoni Luigi Barberini Cristina Piras Pier Paolo Bassareo Maurizio Porcu Giuseppe Mercuro Christian Cadeddu Dessalvi
author_facet	Martino Deidda Antonio Noto Daniele Pasqualucci Claudia Fattuoni Luigi Barberini Cristina Piras Pier Paolo Bassareo Maurizio Porcu Giuseppe Mercuro Christian Cadeddu Dessalvi
author_sort	Martino Deidda
title	The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy
title_short	The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy
title_full	The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy
title_fullStr	The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy
title_full_unstemmed	The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy
title_sort	echocardiographic parameters of systolic function are associated with specific metabolomic fingerprints in obstructive and non-obstructive hypertrophic cardiomyopathy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f66d553cb4904707a448518ed320d59a
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The Echocardiographic Parameters of Systolic Function Are Associated with Specific Metabolomic Fingerprints in Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy

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