Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

ABSTRACT A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying mechanisms or the potential role of Fc-mediated e...

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Autores principales: M. Muenchhoff, A. W. Chung, J. Roider, Anne-Sophie Dugast, Simone Richardson, Henrik Kløverpris, Alasdair Leslie, Thumbi Ndung’u, Penny Moore, Galit Alter, Philip J. R. Goulder
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Fc effector functions
Fc glycosylation
HIV
broadly neutralizing antibodies (bnAbs)
nonneutralizing antibodies
pediatric
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/f66d862dd1194fa4867e6134d3109279
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