An intensity matched comparison of laser- and contact heat evoked potentials

Abstract Previous studies comparing laser (LEPs) and contact heat evoked potentials (CHEPs) consistently reported higher amplitudes following laser compared to contact heat stimulation. However, none of the studies matched the perceived pain intensity, questioning if the observed difference in ampli...

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Autores principales:	Iara De Schoenmacker, Carson Berry, Jean-Sébastien Blouin, Jan Rosner, Michèle Hubli, Catherine R. Jutzeler, John L. K. Kramer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f6711eb6637448069ccc432798a6641d
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spelling	oai:doaj.org-article:f6711eb6637448069ccc432798a6641d2021-12-02T13:24:26ZAn intensity matched comparison of laser- and contact heat evoked potentials10.1038/s41598-021-85819-w2045-2322https://doaj.org/article/f6711eb6637448069ccc432798a6641d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85819-whttps://doaj.org/toc/2045-2322Abstract Previous studies comparing laser (LEPs) and contact heat evoked potentials (CHEPs) consistently reported higher amplitudes following laser compared to contact heat stimulation. However, none of the studies matched the perceived pain intensity, questioning if the observed difference in amplitude is due to biophysical differences between the two methods or a mismatch in stimulation intensity. The aims of the current study were twofold: (1) to directly compare the brain potentials induced by intensity matched laser and contact heat stimulation and (2) investigate how capsaicin-induced secondary hyperalgesia modulates LEPs and CHEPs. Twenty-one healthy subjects were recruited and measured at four experimental sessions: (1) CHEPs + sham, (2) LEPs + sham, (3) CHEPs + capsaicin, and (4) LEPs + capsaicin. Baseline (sham) LEPs latency was significantly shorter and amplitude significantly larger compared to CHEPs, even when matched for perceived pain. Neither CHEPs nor LEPs was sensitive enough to detect secondary hyperalgesia. These differences provide evidence that a faster heating rate results in an earlier and more synchronized LEPs than CHEPs. To our knowledge, this was the first study to match perceived intensity of contact heat and laser stimulations, revealing distinct advantages associated with the acquisition of LEPs.Iara De SchoenmackerCarson BerryJean-Sébastien BlouinJan RosnerMichèle HubliCatherine R. JutzelerJohn L. K. KramerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iara De Schoenmacker Carson Berry Jean-Sébastien Blouin Jan Rosner Michèle Hubli Catherine R. Jutzeler John L. K. Kramer An intensity matched comparison of laser- and contact heat evoked potentials
description	Abstract Previous studies comparing laser (LEPs) and contact heat evoked potentials (CHEPs) consistently reported higher amplitudes following laser compared to contact heat stimulation. However, none of the studies matched the perceived pain intensity, questioning if the observed difference in amplitude is due to biophysical differences between the two methods or a mismatch in stimulation intensity. The aims of the current study were twofold: (1) to directly compare the brain potentials induced by intensity matched laser and contact heat stimulation and (2) investigate how capsaicin-induced secondary hyperalgesia modulates LEPs and CHEPs. Twenty-one healthy subjects were recruited and measured at four experimental sessions: (1) CHEPs + sham, (2) LEPs + sham, (3) CHEPs + capsaicin, and (4) LEPs + capsaicin. Baseline (sham) LEPs latency was significantly shorter and amplitude significantly larger compared to CHEPs, even when matched for perceived pain. Neither CHEPs nor LEPs was sensitive enough to detect secondary hyperalgesia. These differences provide evidence that a faster heating rate results in an earlier and more synchronized LEPs than CHEPs. To our knowledge, this was the first study to match perceived intensity of contact heat and laser stimulations, revealing distinct advantages associated with the acquisition of LEPs.
format	article
author	Iara De Schoenmacker Carson Berry Jean-Sébastien Blouin Jan Rosner Michèle Hubli Catherine R. Jutzeler John L. K. Kramer
author_facet	Iara De Schoenmacker Carson Berry Jean-Sébastien Blouin Jan Rosner Michèle Hubli Catherine R. Jutzeler John L. K. Kramer
author_sort	Iara De Schoenmacker
title	An intensity matched comparison of laser- and contact heat evoked potentials
title_short	An intensity matched comparison of laser- and contact heat evoked potentials
title_full	An intensity matched comparison of laser- and contact heat evoked potentials
title_fullStr	An intensity matched comparison of laser- and contact heat evoked potentials
title_full_unstemmed	An intensity matched comparison of laser- and contact heat evoked potentials
title_sort	intensity matched comparison of laser- and contact heat evoked potentials
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f6711eb6637448069ccc432798a6641d
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An intensity matched comparison of laser- and contact heat evoked potentials

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