New and emerging treatment approaches to lupus

Marion HaubitzDepartment of Nephrology, Medical School Hannover, Hanover, GermanyAbstract: The main goal in systemic lupus erythematosus (SLE) is to achieve remission, as this has a major impact on patient and renal survival. Furthermore, early treatment success has been shown to improve long-term p...

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Autor principal:	Marion Haubitz
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f674c9d29a8c422a96c415e56b8b05ca
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spelling	oai:doaj.org-article:f674c9d29a8c422a96c415e56b8b05ca2021-12-02T01:44:40ZNew and emerging treatment approaches to lupus1177-54751177-5491https://doaj.org/article/f674c9d29a8c422a96c415e56b8b05ca2010-09-01T00:00:00Zhttp://www.dovepress.com/new-and-emerging-treatment-approaches-to-lupus-a5208https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Marion HaubitzDepartment of Nephrology, Medical School Hannover, Hanover, GermanyAbstract: The main goal in systemic lupus erythematosus (SLE) is to achieve remission, as this has a major impact on patient and renal survival. Furthermore, early treatment success has been shown to improve long-term prognosis. Treatment in severe SLE, especially in lupus nephritis, has traditionally been a standardized schematic therapy with cyclophosphamide and prednisolone followed by azathioprine. However, animal and human studies have increased our pathogenetic knowledge of this autoimmune disease with emerging new treatment targets. New and future therapeutic approaches are focused on B-cell depletion, T-cell downregulation and co-stimulatory blockade, cytokine inhibition, or the modulation of complement. Many different biological agents have been used in recent and ongoing studies, but up to now breakthroughs emerging from randomized Phase III trials have been rare. However, the future remains exciting with progress towards safe treatments with which to control the disease in the long run.Keywords: systemic lupus erythematosus, lupus nephritis, B-cell depletion, co-stimulatory blockade, cytokine inhibition, monoclonal antibodies Marion HaubitzDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 263-271 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Marion Haubitz New and emerging treatment approaches to lupus
description	Marion HaubitzDepartment of Nephrology, Medical School Hannover, Hanover, GermanyAbstract: The main goal in systemic lupus erythematosus (SLE) is to achieve remission, as this has a major impact on patient and renal survival. Furthermore, early treatment success has been shown to improve long-term prognosis. Treatment in severe SLE, especially in lupus nephritis, has traditionally been a standardized schematic therapy with cyclophosphamide and prednisolone followed by azathioprine. However, animal and human studies have increased our pathogenetic knowledge of this autoimmune disease with emerging new treatment targets. New and future therapeutic approaches are focused on B-cell depletion, T-cell downregulation and co-stimulatory blockade, cytokine inhibition, or the modulation of complement. Many different biological agents have been used in recent and ongoing studies, but up to now breakthroughs emerging from randomized Phase III trials have been rare. However, the future remains exciting with progress towards safe treatments with which to control the disease in the long run.Keywords: systemic lupus erythematosus, lupus nephritis, B-cell depletion, co-stimulatory blockade, cytokine inhibition, monoclonal antibodies
format	article
author	Marion Haubitz
author_facet	Marion Haubitz
author_sort	Marion Haubitz
title	New and emerging treatment approaches to lupus
title_short	New and emerging treatment approaches to lupus
title_full	New and emerging treatment approaches to lupus
title_fullStr	New and emerging treatment approaches to lupus
title_full_unstemmed	New and emerging treatment approaches to lupus
title_sort	new and emerging treatment approaches to lupus
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/f674c9d29a8c422a96c415e56b8b05ca
work_keys_str_mv	AT marionhaubitz newandemergingtreatmentapproachestolupus
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New and emerging treatment approaches to lupus

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