Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria

Xiaolin Zhang,1,* Shuang Zhou,2,* Kunming Pan,2 Xinran Li,2 Xia Zhao,2 Ying Zhou,2 Yimin Cui,2 Xinmin Liu1 1Department of Geriatrics, 2Department of Pharmacy, Peking University First Hospital, Beijing, China *These authors contributed equally to this work Aim: Polypharmacy and p...

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Autores principales:	Zhang X, Zhou S, Pan K, Li X, Zhao X, Zhou Y, Cui Y, Liu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Beers criteria Inappropriate prescription Polypharmacy Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f676b98ef84240a1856188098cf197ef
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spelling	oai:doaj.org-article:f676b98ef84240a1856188098cf197ef2021-12-02T07:25:53ZPotentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria1178-1998https://doaj.org/article/f676b98ef84240a1856188098cf197ef2017-10-01T00:00:00Zhttps://www.dovepress.com/potentially-inappropriate-medications-in-hospitalized-older-patients-a-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xiaolin Zhang,1,* Shuang Zhou,2,* Kunming Pan,2 Xinran Li,2 Xia Zhao,2 Ying Zhou,2 Yimin Cui,2 Xinmin Liu1 1Department of Geriatrics, 2Department of Pharmacy, Peking University First Hospital, Beijing, China *These authors contributed equally to this work Aim: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients. The purpose of the study was to investigate the prevalence of PIMs identified by the Beers 2015 and 2012 criteria in older patients in China and identify the correlates of PIMs.Methods: This retrospective, cross-sectional study was conducted at Peking University First Hospital. The Beers 2015 and 2012 criteria were applied to evaluate PIMs among hospitalized patients. The associations between PIM use and independent variables were analyzed by logistic regression. The differences between PIM use according to Beers 2012 and 2015 criteria were calculated using chi-squared and kappa tests.Results: A total of 456 patients were analyzed; 244 (53.5%) and 204 (44.7%) patients had at least one PIM identified by the Beers 2015 and 2012 criteria, respectively. The most frequent PIMs were proton-pump inhibitors (PPIs), benzodiazepines, and benzodiazepine receptor agonists according to the Beers 2015 criteria. PIMs identified by the Beers 2015 criteria were associated with excessive polypharmacy (OR 1.864, 95% CI 1.210–2.871), a Barthel index ≤60 (OR 1.935, 95% CI 1.056–3.546), and the length of stay (OR 1.066, 95% CI 1.037–1.097). PIM use increased significantly between two criteria (chi-squared test, P<0.001), but good accordance was found between the previous and updated criteria (kappa test 0.782, P<0.001).Conclusion: Our study showed a high prevalence of PIM use in China, which was associated with various correlates. The Beers 2015 criteria detected significantly more PIMs than the 2012 criteria due to the inclusion of PPIs. Keywords: Beers criteria, inappropriate prescription, polypharmacyZhang XZhou SPan KLi XZhao XZhou YCui YLiu XDove Medical PressarticleBeers criteriaInappropriate prescriptionPolypharmacyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1697-1703 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Beers criteria Inappropriate prescription Polypharmacy Geriatrics RC952-954.6
spellingShingle	Beers criteria Inappropriate prescription Polypharmacy Geriatrics RC952-954.6 Zhang X Zhou S Pan K Li X Zhao X Zhou Y Cui Y Liu X Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria
description	Xiaolin Zhang,1,* Shuang Zhou,2,* Kunming Pan,2 Xinran Li,2 Xia Zhao,2 Ying Zhou,2 Yimin Cui,2 Xinmin Liu1 1Department of Geriatrics, 2Department of Pharmacy, Peking University First Hospital, Beijing, China *These authors contributed equally to this work Aim: Polypharmacy and potentially inappropriate medications (PIMs) are prominent prescribing issues in elderly patients. The purpose of the study was to investigate the prevalence of PIMs identified by the Beers 2015 and 2012 criteria in older patients in China and identify the correlates of PIMs.Methods: This retrospective, cross-sectional study was conducted at Peking University First Hospital. The Beers 2015 and 2012 criteria were applied to evaluate PIMs among hospitalized patients. The associations between PIM use and independent variables were analyzed by logistic regression. The differences between PIM use according to Beers 2012 and 2015 criteria were calculated using chi-squared and kappa tests.Results: A total of 456 patients were analyzed; 244 (53.5%) and 204 (44.7%) patients had at least one PIM identified by the Beers 2015 and 2012 criteria, respectively. The most frequent PIMs were proton-pump inhibitors (PPIs), benzodiazepines, and benzodiazepine receptor agonists according to the Beers 2015 criteria. PIMs identified by the Beers 2015 criteria were associated with excessive polypharmacy (OR 1.864, 95% CI 1.210–2.871), a Barthel index ≤60 (OR 1.935, 95% CI 1.056–3.546), and the length of stay (OR 1.066, 95% CI 1.037–1.097). PIM use increased significantly between two criteria (chi-squared test, P<0.001), but good accordance was found between the previous and updated criteria (kappa test 0.782, P<0.001).Conclusion: Our study showed a high prevalence of PIM use in China, which was associated with various correlates. The Beers 2015 criteria detected significantly more PIMs than the 2012 criteria due to the inclusion of PPIs. Keywords: Beers criteria, inappropriate prescription, polypharmacy
format	article
author	Zhang X Zhou S Pan K Li X Zhao X Zhou Y Cui Y Liu X
author_facet	Zhang X Zhou S Pan K Li X Zhao X Zhou Y Cui Y Liu X
author_sort	Zhang X
title	Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria
title_short	Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria
title_full	Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria
title_fullStr	Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria
title_full_unstemmed	Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria
title_sort	potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the beers 2015 criteria versus the 2012 criteria
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f676b98ef84240a1856188098cf197ef
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Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria

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