TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer
KRAS mutation is very common in pancreatic cancer. How pancreatic cancer cells overcome oncogene-induced senescence is not fully understood. Our previous studies showed that up-regulation of TFCP2 (transcription factor CP2) in pancreatic cancer promoted the growth and metastasis of pancreatic cancer...
Guardado en:
Autores principales: | Dexiang Zhang, Pinxiang Lu, Kaihua Zhu, Haixia Wu, Yuedi Dai |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/f678d0af0f334452ab13a748b4f421a9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal
por: Yan Zhang, et al.
Publicado: (2021) -
RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
por: Wang,Guangchuan, et al.
Publicado: (2019) -
Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer
por: Cecilia R. Chambers, et al.
Publicado: (2021) -
The Dual Role of Senescence in Tumorigenesis
por: Chuaire-Noack,Lilian, et al.
Publicado: (2010) -
Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
por: Nathalie Thorin-Trescases, et al.
Publicado: (2021)