Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients
Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA) and early diagnosis is crucial for the management of PsA. Here, Patrick et al. develop a computational pipeline involving statistical and machine-learning methods that can assess the risk of progression to PsA based on genetic...
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Nature Portfolio
2018
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oai:doaj.org-article:f67954f1b8fa41a1be488a5ddddc158b2021-12-02T15:33:42ZGenetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients10.1038/s41467-018-06672-62041-1723https://doaj.org/article/f67954f1b8fa41a1be488a5ddddc158b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06672-6https://doaj.org/toc/2041-1723Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA) and early diagnosis is crucial for the management of PsA. Here, Patrick et al. develop a computational pipeline involving statistical and machine-learning methods that can assess the risk of progression to PsA based on genetic markers.Matthew T. PatrickPhilip E. StuartKalpana RajaJohann E. GudjonssonTrilokraj TejasviJingjing YangVinod ChandranSayantan DasKristina Callis-DuffinEva EllinghausCharlotta EnerbäckTõnu EskoAndre FrankeHyun M. KangGerald G. KruegerHenry W. LimProton RahmanCheryl F. RosenStephan WeidingerMichael WeichenthalXiaoquan WenJohn J. VoorheesGonçalo R. AbecasisDafna D. GladmanRajan P. NairJames T. ElderLam C. TsoiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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DOAJ |
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EN |
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Science Q |
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Science Q Matthew T. Patrick Philip E. Stuart Kalpana Raja Johann E. Gudjonsson Trilokraj Tejasvi Jingjing Yang Vinod Chandran Sayantan Das Kristina Callis-Duffin Eva Ellinghaus Charlotta Enerbäck Tõnu Esko Andre Franke Hyun M. Kang Gerald G. Krueger Henry W. Lim Proton Rahman Cheryl F. Rosen Stephan Weidinger Michael Weichenthal Xiaoquan Wen John J. Voorhees Gonçalo R. Abecasis Dafna D. Gladman Rajan P. Nair James T. Elder Lam C. Tsoi Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients |
| description |
Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA) and early diagnosis is crucial for the management of PsA. Here, Patrick et al. develop a computational pipeline involving statistical and machine-learning methods that can assess the risk of progression to PsA based on genetic markers. |
| format |
article |
| author |
Matthew T. Patrick Philip E. Stuart Kalpana Raja Johann E. Gudjonsson Trilokraj Tejasvi Jingjing Yang Vinod Chandran Sayantan Das Kristina Callis-Duffin Eva Ellinghaus Charlotta Enerbäck Tõnu Esko Andre Franke Hyun M. Kang Gerald G. Krueger Henry W. Lim Proton Rahman Cheryl F. Rosen Stephan Weidinger Michael Weichenthal Xiaoquan Wen John J. Voorhees Gonçalo R. Abecasis Dafna D. Gladman Rajan P. Nair James T. Elder Lam C. Tsoi |
| author_facet |
Matthew T. Patrick Philip E. Stuart Kalpana Raja Johann E. Gudjonsson Trilokraj Tejasvi Jingjing Yang Vinod Chandran Sayantan Das Kristina Callis-Duffin Eva Ellinghaus Charlotta Enerbäck Tõnu Esko Andre Franke Hyun M. Kang Gerald G. Krueger Henry W. Lim Proton Rahman Cheryl F. Rosen Stephan Weidinger Michael Weichenthal Xiaoquan Wen John J. Voorhees Gonçalo R. Abecasis Dafna D. Gladman Rajan P. Nair James T. Elder Lam C. Tsoi |
| author_sort |
Matthew T. Patrick |
| title |
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients |
| title_short |
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients |
| title_full |
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients |
| title_fullStr |
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients |
| title_full_unstemmed |
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients |
| title_sort |
genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/f67954f1b8fa41a1be488a5ddddc158b |
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