Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.

The role of Type I interferon (IFN) during pathogenic HIV and SIV infections remains unclear, with conflicting observations suggesting protective versus immunopathological effects. We therefore examined the effect of IFNα/β on T cell death and viremia in HIV infection. Ex vivo analysis of eight pro-...

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Autores principales:	Joseph A Fraietta, Yvonne M Mueller, Guibin Yang, Alina C Boesteanu, Donald T Gracias, Duc H Do, Jennifer L Hope, Noshin Kathuria, Shannon E McGettigan, Mark G Lewis, Luis D Giavedoni, Jeffrey M Jacobson, Peter D Katsikis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f681ebe2086b4e1387218826ddfdc7cf
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Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.

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