Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings

Phatcharawat Chirasuthat, Suthep Chirasuthat, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine...

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Autores principales:	Chirasuthat P, Chirasuthat S, Suchonwanit P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ellulitis dermis edema-phage lymphedema pseudocellulitis volume overload Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f686143984ef4be0a89868c99b417145
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spelling	oai:doaj.org-article:f686143984ef4be0a89868c99b4171452021-12-02T17:44:33ZAcute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings1178-7031https://doaj.org/article/f686143984ef4be0a89868c99b4171452021-09-01T00:00:00Zhttps://www.dovepress.com/acute-inflammatory-edema-a-case-report-with-histopathological-and-immu-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Phatcharawat Chirasuthat, Suthep Chirasuthat, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, ThailandTel +66-2-2011141Fax +66-2-201-1211 ext 4Email poonkiat@hotmail.comAbstract: Acute inflammatory edema (AIE) is a rare variant of pseudocellulitis characterized by blanchable, erythematous, and edematous plaques mainly on the thighs and abdomen and sparing areas of increased pressure. The condition occurs predominantly in critically ill patients with hypoalbuminemia, those with increased body mass index, and those with evidence of fluid overload. AIE was introduced in 2019; however, its histopathological picture has never been elucidated in the literature. We report a case of AIE in a 64-year-old Thai woman with several comorbidities and illustrate its histopathological and immunohistochemical features for the first time. Treatment with diuretics, fluid restriction, and adjuvant hemodialysis revealed marked improvement after ten days. Our report emphasizes that AIE is a distinct dermatosis with specific characteristics that help differentiate AIE from cellulitis and other pseudocellulitic conditions. Furthermore, our observations support the role of lymphatic alterations in the pathogenesis of the disease.Keywords: cellulitis, dermis, edema-phage, lymphedema, pseudocellulitis, volume overloadChirasuthat PChirasuthat SSuchonwanit PDove Medical Pressarticleellulitisdermisedema-phagelymphedemapseudocellulitisvolume overloadPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 4877-4880 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ellulitis dermis edema-phage lymphedema pseudocellulitis volume overload Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ellulitis dermis edema-phage lymphedema pseudocellulitis volume overload Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Chirasuthat P Chirasuthat S Suchonwanit P Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings
description	Phatcharawat Chirasuthat, Suthep Chirasuthat, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, ThailandTel +66-2-2011141Fax +66-2-201-1211 ext 4Email poonkiat@hotmail.comAbstract: Acute inflammatory edema (AIE) is a rare variant of pseudocellulitis characterized by blanchable, erythematous, and edematous plaques mainly on the thighs and abdomen and sparing areas of increased pressure. The condition occurs predominantly in critically ill patients with hypoalbuminemia, those with increased body mass index, and those with evidence of fluid overload. AIE was introduced in 2019; however, its histopathological picture has never been elucidated in the literature. We report a case of AIE in a 64-year-old Thai woman with several comorbidities and illustrate its histopathological and immunohistochemical features for the first time. Treatment with diuretics, fluid restriction, and adjuvant hemodialysis revealed marked improvement after ten days. Our report emphasizes that AIE is a distinct dermatosis with specific characteristics that help differentiate AIE from cellulitis and other pseudocellulitic conditions. Furthermore, our observations support the role of lymphatic alterations in the pathogenesis of the disease.Keywords: cellulitis, dermis, edema-phage, lymphedema, pseudocellulitis, volume overload
format	article
author	Chirasuthat P Chirasuthat S Suchonwanit P
author_facet	Chirasuthat P Chirasuthat S Suchonwanit P
author_sort	Chirasuthat P
title	Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings
title_short	Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings
title_full	Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings
title_fullStr	Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings
title_full_unstemmed	Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings
title_sort	acute inflammatory edema: a case report with histopathological and immunohistochemical findings
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f686143984ef4be0a89868c99b417145
work_keys_str_mv	AT chirasuthatp acuteinflammatoryedemaacasereportwithhistopathologicalandimmunohistochemicalfindings AT chirasuthats acuteinflammatoryedemaacasereportwithhistopathologicalandimmunohistochemicalfindings AT suchonwanitp acuteinflammatoryedemaacasereportwithhistopathologicalandimmunohistochemicalfindings
_version_	1718379681488568320

Acute Inflammatory Edema: A Case Report with Histopathological and Immunohistochemical Findings

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