Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence. The proposed axis is crucial to promote the inflammatory senescence-associated secretory phenotyp...

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Autores principales:	Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f687034dd13c48c997ad226023ef1a47
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spelling	oai:doaj.org-article:f687034dd13c48c997ad226023ef1a472021-12-02T14:40:51ZTopoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence10.1038/s41467-020-14652-y2041-1723https://doaj.org/article/f687034dd13c48c997ad226023ef1a472020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14652-yhttps://doaj.org/toc/2041-1723Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence. The proposed axis is crucial to promote the inflammatory senescence-associated secretory phenotype and to enable the response to immune checkpoint blockade.Bo ZhaoPingyu LiuTakeshi FukumotoTimothy NacarelliNail FatkhutdinovShuai WuJianhuang LinKatherine M. AirdHsin-Yao TangQin LiuDavid W. SpeicherRugang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Zhao Pingyu Liu Takeshi Fukumoto Timothy Nacarelli Nail Fatkhutdinov Shuai Wu Jianhuang Lin Katherine M. Aird Hsin-Yao Tang Qin Liu David W. Speicher Rugang Zhang Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
description	Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence. The proposed axis is crucial to promote the inflammatory senescence-associated secretory phenotype and to enable the response to immune checkpoint blockade.
format	article
author	Bo Zhao Pingyu Liu Takeshi Fukumoto Timothy Nacarelli Nail Fatkhutdinov Shuai Wu Jianhuang Lin Katherine M. Aird Hsin-Yao Tang Qin Liu David W. Speicher Rugang Zhang
author_facet	Bo Zhao Pingyu Liu Takeshi Fukumoto Timothy Nacarelli Nail Fatkhutdinov Shuai Wu Jianhuang Lin Katherine M. Aird Hsin-Yao Tang Qin Liu David W. Speicher Rugang Zhang
author_sort	Bo Zhao
title	Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
title_short	Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
title_full	Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
title_fullStr	Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
title_full_unstemmed	Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
title_sort	topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f687034dd13c48c997ad226023ef1a47
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

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