Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

Many human proteins are regulated by lysine acetylation, but the degree of acetylation at individual sites is poorly characterized. Here, the authors measure acetylation stoichiometry in the HeLa cell proteome, providing a resource to assess mechanistic constraints on acetylation-mediated protein re...

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Autores principales:	Bogi Karbech Hansen, Rajat Gupta, Linda Baldus, David Lyon, Takeo Narita, Michael Lammers, Chunaram Choudhary, Brian T. Weinert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f689076cde19400e8edea6f60e39f647
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spelling	oai:doaj.org-article:f689076cde19400e8edea6f60e39f6472021-12-02T15:35:57ZAnalysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation10.1038/s41467-019-09024-02041-1723https://doaj.org/article/f689076cde19400e8edea6f60e39f6472019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09024-0https://doaj.org/toc/2041-1723Many human proteins are regulated by lysine acetylation, but the degree of acetylation at individual sites is poorly characterized. Here, the authors measure acetylation stoichiometry in the HeLa cell proteome, providing a resource to assess mechanistic constraints on acetylation-mediated protein regulation.Bogi Karbech HansenRajat GuptaLinda BaldusDavid LyonTakeo NaritaMichael LammersChunaram ChoudharyBrian T. WeinertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bogi Karbech Hansen Rajat Gupta Linda Baldus David Lyon Takeo Narita Michael Lammers Chunaram Choudhary Brian T. Weinert Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
description	Many human proteins are regulated by lysine acetylation, but the degree of acetylation at individual sites is poorly characterized. Here, the authors measure acetylation stoichiometry in the HeLa cell proteome, providing a resource to assess mechanistic constraints on acetylation-mediated protein regulation.
format	article
author	Bogi Karbech Hansen Rajat Gupta Linda Baldus David Lyon Takeo Narita Michael Lammers Chunaram Choudhary Brian T. Weinert
author_facet	Bogi Karbech Hansen Rajat Gupta Linda Baldus David Lyon Takeo Narita Michael Lammers Chunaram Choudhary Brian T. Weinert
author_sort	Bogi Karbech Hansen
title	Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
title_short	Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
title_full	Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
title_fullStr	Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
title_full_unstemmed	Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
title_sort	analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f689076cde19400e8edea6f60e39f647
work_keys_str_mv	AT bogikarbechhansen analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation AT rajatgupta analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation AT lindabaldus analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation AT davidlyon analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation AT takeonarita analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation AT michaellammers analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation AT chunaramchoudhary analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation AT briantweinert analysisofhumanacetylationstoichiometrydefinesmechanisticconstraintsonproteinregulation
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Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

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