Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome

Introduction: Lichen planus/lupus erythematosus overlap syndrome is rarely seen in the clinic and has the characteristic clinical manifestations, histopathology, and immunopathology of lichen planus (LP) and lupus erythematosus (LE). This is the first reported case of bullous lichen planus (BLP)/sys...

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Autores principales:	Yi Liu, Xuelei Liang, Haixuan Wu, Fenglin Zhuo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bullous lichen planus systemic lupus erythematosus overlap syndrome case report alopecia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f68a62d093bd41ada9fa1563b81b191e
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spelling	oai:doaj.org-article:f68a62d093bd41ada9fa1563b81b191e2021-11-04T06:23:18ZCase Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome2296-858X10.3389/fmed.2021.744592https://doaj.org/article/f68a62d093bd41ada9fa1563b81b191e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.744592/fullhttps://doaj.org/toc/2296-858XIntroduction: Lichen planus/lupus erythematosus overlap syndrome is rarely seen in the clinic and has the characteristic clinical manifestations, histopathology, and immunopathology of lichen planus (LP) and lupus erythematosus (LE). This is the first reported case of bullous lichen planus (BLP)/systemic lupus erythematosus (SLE) overlap syndrome with hair loss as the first symptom.Case Presentation: A 48-year-old female presented with alopecia for half a year, and skin lesions accompanied by itching on her face, trunk, and limbs for 3 months. She had a history suggestive of photosensitivity. Laboratory tests and histopathology were performed for diagnosis. Histopathologic features of the upper arm and back of the hand were consistent with BLP, whereas the scalp lesion indicated LE. Laboratory examination indicated positive for antinuclear antibody (ANA) (1:160), leukopenia, increased urinary protein, decreased C3/C4, and normal BP180. The patient was given glucocorticoid combined with acitretin and immunosuppressive therapy after a definite diagnosis of BLP/SLE overlap syndrome. The lesions of the patient disappeared and some hair had regrown during the two years of follow-up.Conclusion: This is the first reported case of BLP/SLE overlap syndrome which responded well to glucocorticoids, retinoids, and immunosuppressive drugs. Multiple biopsies from characteristic lesions will guide doctors to avoid misdiagnoses and delayed treatment.Yi LiuXuelei LiangHaixuan WuFenglin ZhuoFrontiers Media S.A.articlebullous lichen planussystemic lupus erythematosusoverlap syndromecase reportalopeciaMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bullous lichen planus systemic lupus erythematosus overlap syndrome case report alopecia Medicine (General) R5-920
spellingShingle	bullous lichen planus systemic lupus erythematosus overlap syndrome case report alopecia Medicine (General) R5-920 Yi Liu Xuelei Liang Haixuan Wu Fenglin Zhuo Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome
description	Introduction: Lichen planus/lupus erythematosus overlap syndrome is rarely seen in the clinic and has the characteristic clinical manifestations, histopathology, and immunopathology of lichen planus (LP) and lupus erythematosus (LE). This is the first reported case of bullous lichen planus (BLP)/systemic lupus erythematosus (SLE) overlap syndrome with hair loss as the first symptom.Case Presentation: A 48-year-old female presented with alopecia for half a year, and skin lesions accompanied by itching on her face, trunk, and limbs for 3 months. She had a history suggestive of photosensitivity. Laboratory tests and histopathology were performed for diagnosis. Histopathologic features of the upper arm and back of the hand were consistent with BLP, whereas the scalp lesion indicated LE. Laboratory examination indicated positive for antinuclear antibody (ANA) (1:160), leukopenia, increased urinary protein, decreased C3/C4, and normal BP180. The patient was given glucocorticoid combined with acitretin and immunosuppressive therapy after a definite diagnosis of BLP/SLE overlap syndrome. The lesions of the patient disappeared and some hair had regrown during the two years of follow-up.Conclusion: This is the first reported case of BLP/SLE overlap syndrome which responded well to glucocorticoids, retinoids, and immunosuppressive drugs. Multiple biopsies from characteristic lesions will guide doctors to avoid misdiagnoses and delayed treatment.
format	article
author	Yi Liu Xuelei Liang Haixuan Wu Fenglin Zhuo
author_facet	Yi Liu Xuelei Liang Haixuan Wu Fenglin Zhuo
author_sort	Yi Liu
title	Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome
title_short	Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome
title_full	Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome
title_fullStr	Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome
title_full_unstemmed	Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome
title_sort	case report: the first reported case of bullous lichen planus-systemic lupus erythematosus overlap syndrome
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f68a62d093bd41ada9fa1563b81b191e
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Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome

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