Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana.
Scaffold/matrix attachment regions (S/MARs) are essential for structural organization of the chromatin within the nucleus and serve as anchors of chromatin loop domains. A significant fraction of genes in Arabidopsis thaliana contains intragenic S/MAR elements and a significant correlation of S/MAR...
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Public Library of Science (PLoS)
2006
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oai:doaj.org-article:f68cc273e42042debfd3449e4662b53d2021-11-25T05:41:08ZSpatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana.1553-734X1553-735810.1371/journal.pcbi.0020021https://doaj.org/article/f68cc273e42042debfd3449e4662b53d2006-03-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.0020021https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Scaffold/matrix attachment regions (S/MARs) are essential for structural organization of the chromatin within the nucleus and serve as anchors of chromatin loop domains. A significant fraction of genes in Arabidopsis thaliana contains intragenic S/MAR elements and a significant correlation of S/MAR presence and overall expression strength has been demonstrated. In this study, we undertook a genome scale analysis of expression level and spatiotemporal expression differences in correlation with the presence or absence of genic S/MAR elements. We demonstrate that genes containing intragenic S/MARs are prone to pronounced spatiotemporal expression regulation. This characteristic is found to be even more pronounced for transcription factor genes. Our observations illustrate the importance of S/MARs in transcriptional regulation and the role of chromatin structural characteristics for gene regulation. Our findings open new perspectives for the understanding of tissue- and organ-specific regulation of gene expression.Igor V TetkoGeorg HabererStephen RuddBlake MeyersHans-Werner MewesKlaus F X MayerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 2, Iss 3, p e21 (2006) |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Igor V Tetko Georg Haberer Stephen Rudd Blake Meyers Hans-Werner Mewes Klaus F X Mayer Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana. |
| description |
Scaffold/matrix attachment regions (S/MARs) are essential for structural organization of the chromatin within the nucleus and serve as anchors of chromatin loop domains. A significant fraction of genes in Arabidopsis thaliana contains intragenic S/MAR elements and a significant correlation of S/MAR presence and overall expression strength has been demonstrated. In this study, we undertook a genome scale analysis of expression level and spatiotemporal expression differences in correlation with the presence or absence of genic S/MAR elements. We demonstrate that genes containing intragenic S/MARs are prone to pronounced spatiotemporal expression regulation. This characteristic is found to be even more pronounced for transcription factor genes. Our observations illustrate the importance of S/MARs in transcriptional regulation and the role of chromatin structural characteristics for gene regulation. Our findings open new perspectives for the understanding of tissue- and organ-specific regulation of gene expression. |
| format |
article |
| author |
Igor V Tetko Georg Haberer Stephen Rudd Blake Meyers Hans-Werner Mewes Klaus F X Mayer |
| author_facet |
Igor V Tetko Georg Haberer Stephen Rudd Blake Meyers Hans-Werner Mewes Klaus F X Mayer |
| author_sort |
Igor V Tetko |
| title |
Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana. |
| title_short |
Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana. |
| title_full |
Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana. |
| title_fullStr |
Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana. |
| title_full_unstemmed |
Spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (S/MARs) in Arabidopsis thaliana. |
| title_sort |
spatiotemporal expression control correlates with intragenic scaffold matrix attachment regions (s/mars) in arabidopsis thaliana. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2006 |
| url |
https://doaj.org/article/f68cc273e42042debfd3449e4662b53d |
| work_keys_str_mv |
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| _version_ |
1718414554782760960 |