Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance

Both thymic epithelial cells and dendritic cells present self antigens in the thymus to mediate thymic selection and T cell tolerance. Here the authors quantify, using two-photon live imaging of mouse thymic slices, the relative contribution of these two cell types, as well as the effects of antigen...

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Autores principales:	J. N. Lancaster, H. M. Thyagarajan, J. Srinivasan, Y. Li, Z. Hu, L. I. R. Ehrlich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f690393b9d224291a50a4eb2bf28dd24
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spelling	oai:doaj.org-article:f690393b9d224291a50a4eb2bf28dd242021-12-02T16:58:27ZLive-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance10.1038/s41467-019-09727-42041-1723https://doaj.org/article/f690393b9d224291a50a4eb2bf28dd242019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09727-4https://doaj.org/toc/2041-1723Both thymic epithelial cells and dendritic cells present self antigens in the thymus to mediate thymic selection and T cell tolerance. Here the authors quantify, using two-photon live imaging of mouse thymic slices, the relative contribution of these two cell types, as well as the effects of antigen cross-presentation by dendritic cells, during tolerance induction.J. N. LancasterH. M. ThyagarajanJ. SrinivasanY. LiZ. HuL. I. R. EhrlichNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. N. Lancaster H. M. Thyagarajan J. Srinivasan Y. Li Z. Hu L. I. R. Ehrlich Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
description	Both thymic epithelial cells and dendritic cells present self antigens in the thymus to mediate thymic selection and T cell tolerance. Here the authors quantify, using two-photon live imaging of mouse thymic slices, the relative contribution of these two cell types, as well as the effects of antigen cross-presentation by dendritic cells, during tolerance induction.
format	article
author	J. N. Lancaster H. M. Thyagarajan J. Srinivasan Y. Li Z. Hu L. I. R. Ehrlich
author_facet	J. N. Lancaster H. M. Thyagarajan J. Srinivasan Y. Li Z. Hu L. I. R. Ehrlich
author_sort	J. N. Lancaster
title	Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
title_short	Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
title_full	Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
title_fullStr	Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
title_full_unstemmed	Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
title_sort	live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f690393b9d224291a50a4eb2bf28dd24
work_keys_str_mv	AT jnlancaster livecellimagingrevealstherelativecontributionsofantigenpresentingcellsubsetstothymiccentraltolerance AT hmthyagarajan livecellimagingrevealstherelativecontributionsofantigenpresentingcellsubsetstothymiccentraltolerance AT jsrinivasan livecellimagingrevealstherelativecontributionsofantigenpresentingcellsubsetstothymiccentraltolerance AT yli livecellimagingrevealstherelativecontributionsofantigenpresentingcellsubsetstothymiccentraltolerance AT zhu livecellimagingrevealstherelativecontributionsofantigenpresentingcellsubsetstothymiccentraltolerance AT lirehrlich livecellimagingrevealstherelativecontributionsofantigenpresentingcellsubsetstothymiccentraltolerance
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Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance

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