An ester bond underlies the mechanical strength of a pathogen surface protein

An ester bond underlies the mechanical strength of a pathogen surface protein

Bacterial surface adhesion proteins are characterized by unusual mechanical properties. Here, the authors use atomic force microscopy-based technique to study a surface-anchoring protein Cpe0147 from Clostridium perfringens and show that an ester bond can withstand considerable mechanical forces and...

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Autores principales: Hai Lei, Quan Ma, Wenfei Li, Jing Wen, Haibo Ma, Meng Qin, Wei Wang, Yi Cao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f6921e3e6a71455a9c7080bf0c5fecd1
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spelling oai:doaj.org-article:f6921e3e6a71455a9c7080bf0c5fecd12021-12-02T15:09:09ZAn ester bond underlies the mechanical strength of a pathogen surface protein10.1038/s41467-021-25425-62041-1723https://doaj.org/article/f6921e3e6a71455a9c7080bf0c5fecd12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25425-6https://doaj.org/toc/2041-1723Bacterial surface adhesion proteins are characterized by unusual mechanical properties. Here, the authors use atomic force microscopy-based technique to study a surface-anchoring protein Cpe0147 from Clostridium perfringens and show that an ester bond can withstand considerable mechanical forces and prevent complete protein unfolding.Hai LeiQuan MaWenfei LiJing WenHaibo MaMeng QinWei WangYi CaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hai Lei
Quan Ma
Wenfei Li
Jing Wen
Haibo Ma
Meng Qin
Wei Wang
Yi Cao
An ester bond underlies the mechanical strength of a pathogen surface protein
description Bacterial surface adhesion proteins are characterized by unusual mechanical properties. Here, the authors use atomic force microscopy-based technique to study a surface-anchoring protein Cpe0147 from Clostridium perfringens and show that an ester bond can withstand considerable mechanical forces and prevent complete protein unfolding.
format article
author Hai Lei
Quan Ma
Wenfei Li
Jing Wen
Haibo Ma
Meng Qin
Wei Wang
Yi Cao
author_facet Hai Lei
Quan Ma
Wenfei Li
Jing Wen
Haibo Ma
Meng Qin
Wei Wang
Yi Cao
author_sort Hai Lei
title An ester bond underlies the mechanical strength of a pathogen surface protein
title_short An ester bond underlies the mechanical strength of a pathogen surface protein
title_full An ester bond underlies the mechanical strength of a pathogen surface protein
title_fullStr An ester bond underlies the mechanical strength of a pathogen surface protein
title_full_unstemmed An ester bond underlies the mechanical strength of a pathogen surface protein
title_sort ester bond underlies the mechanical strength of a pathogen surface protein
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f6921e3e6a71455a9c7080bf0c5fecd1
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