ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia

ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia

Abstract MLL-rearranged acute myeloid leukemia (AML) remains a fatal disease with a high rate of relapse and therapeutic failure due to chemotherapy resistance. In analysis of our Affymetrix microarray profiling and chromatin immunoprecipitation (ChIP) assays, we found that ALOX5 is especially down-...

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Bibliographic Details
Main Authors: Yungui Wang, Jennifer R. Skibbe, Chao Hu, Lei Dong, Kyle Ferchen, Rui Su, Chenying Li, Hao Huang, Hengyou Weng, Huilin Huang, Xi Qin, Jie Jin, Jianjun Chen, Xi Jiang
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/f693c34a5ab845d5aef3a46dd809a2a8
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