A New Report of Combined Central and Peripheral Demyelination: A Case Report

Combined central and peripheral demyelination (CCPD) is not encountered frequently in the clinical practice, and it requires a high level of suspicion for diagnosis. We describe a case of a young man who was diagnosed with radiologically isolated syndrome (RIS) after presenting initially with sympto...

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Autores principales:	Foziah Alshamrani, Rawan Alyami, Ibrahim Alghanimi, Reef Alajaji, Modhi Alkhaldi, Abdulla Alamri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	radiologically isolated syndrome multiple sclerosis miller-fisher syndrome combined central and peripheral demyelinating disease MRI GQ1b Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f694d17a87a94f2d817092ef1e945c88
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spelling	oai:doaj.org-article:f694d17a87a94f2d817092ef1e945c882021-11-19T04:48:16ZA New Report of Combined Central and Peripheral Demyelination: A Case Report1664-229510.3389/fneur.2021.730129https://doaj.org/article/f694d17a87a94f2d817092ef1e945c882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.730129/fullhttps://doaj.org/toc/1664-2295Combined central and peripheral demyelination (CCPD) is not encountered frequently in the clinical practice, and it requires a high level of suspicion for diagnosis. We describe a case of a young man who was diagnosed with radiologically isolated syndrome (RIS) after presenting initially with symptoms suggestive of central nervous system (CNS) insult in the form of double vision, slurred speech, left-sided numbness, and unsteadiness. However, on the next day of admission, his neurological examination was remarkable for ataxia, areflexia, and ophthalmoplegia, the typical triad of Miller Fisher syndrome (MFS). After confirming both diagnoses, the final diagnosis of CCPD was made. The challenges one may face to diagnose and treat CCPD urge sharing of similar cases to open the door for further extensive and thorough investigations and to encourage further studies and analysis of available data to come up with consolidated management guidelines for rare disorders.Foziah AlshamraniRawan AlyamiIbrahim AlghanimiReef AlajajiModhi AlkhaldiAbdulla AlamriFrontiers Media S.A.articleradiologically isolated syndromemultiple sclerosismiller-fisher syndromecombined central and peripheral demyelinating diseaseMRIGQ1bNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiologically isolated syndrome multiple sclerosis miller-fisher syndrome combined central and peripheral demyelinating disease MRI GQ1b Neurology. Diseases of the nervous system RC346-429
spellingShingle	radiologically isolated syndrome multiple sclerosis miller-fisher syndrome combined central and peripheral demyelinating disease MRI GQ1b Neurology. Diseases of the nervous system RC346-429 Foziah Alshamrani Rawan Alyami Ibrahim Alghanimi Reef Alajaji Modhi Alkhaldi Abdulla Alamri A New Report of Combined Central and Peripheral Demyelination: A Case Report
description	Combined central and peripheral demyelination (CCPD) is not encountered frequently in the clinical practice, and it requires a high level of suspicion for diagnosis. We describe a case of a young man who was diagnosed with radiologically isolated syndrome (RIS) after presenting initially with symptoms suggestive of central nervous system (CNS) insult in the form of double vision, slurred speech, left-sided numbness, and unsteadiness. However, on the next day of admission, his neurological examination was remarkable for ataxia, areflexia, and ophthalmoplegia, the typical triad of Miller Fisher syndrome (MFS). After confirming both diagnoses, the final diagnosis of CCPD was made. The challenges one may face to diagnose and treat CCPD urge sharing of similar cases to open the door for further extensive and thorough investigations and to encourage further studies and analysis of available data to come up with consolidated management guidelines for rare disorders.
format	article
author	Foziah Alshamrani Rawan Alyami Ibrahim Alghanimi Reef Alajaji Modhi Alkhaldi Abdulla Alamri
author_facet	Foziah Alshamrani Rawan Alyami Ibrahim Alghanimi Reef Alajaji Modhi Alkhaldi Abdulla Alamri
author_sort	Foziah Alshamrani
title	A New Report of Combined Central and Peripheral Demyelination: A Case Report
title_short	A New Report of Combined Central and Peripheral Demyelination: A Case Report
title_full	A New Report of Combined Central and Peripheral Demyelination: A Case Report
title_fullStr	A New Report of Combined Central and Peripheral Demyelination: A Case Report
title_full_unstemmed	A New Report of Combined Central and Peripheral Demyelination: A Case Report
title_sort	new report of combined central and peripheral demyelination: a case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f694d17a87a94f2d817092ef1e945c88
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A New Report of Combined Central and Peripheral Demyelination: A Case Report

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