Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?

Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues. Using polyphenols in counteracting senescence may facilitate the develo...

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Autores principales:	Nicola Alessio, Tiziana Squillaro, Ida Lettiero, Giovanni Galano, Roberto De Rosa, Gianfranco Peluso, Umberto Galderisi, Giovanni Di Bernardo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesenchymal stem cells polyphenols senescence senolytics Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f6962f8ebda14c0f960a5395d7555367
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spelling	oai:doaj.org-article:f6962f8ebda14c0f960a5395d75553672021-11-11T17:05:54ZBiomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?10.3390/ijms2221116191422-00671661-6596https://doaj.org/article/f6962f8ebda14c0f960a5395d75553672021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11619https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues. Using polyphenols in counteracting senescence may facilitate the development of senotherapeutics given their presence in the human diet, their confirmed tolerability and absence of severe side effects, and their role in preventing senescence and inducing the death of senescent cells. Against that background, we evaluated the effect of piceatannol, a natural polyphenol, on the senescence of mesenchymal stromal cells (MSCs), which play a key role in the body’s homeostasis. Among our results, piceatannol reduced the number of senescent cells both after genotoxic stress that induced acute senescence and in senescent replicative cultures. Such senotherapeutics activity, moreover, promoted the recovery of cell proliferation and the stemness properties of MSCs. Altogether, our findings demonstrate piceatannol’s effectiveness in counteracting senescence by targeting its associated pathways and detecting and affecting P53-dependent and P53-independent senescence. Our study thus suggests that, given piceatannol’s various mechanisms to accomplish its pleiotropic activities, it may be able to counteract any senescent phenotypes.Nicola AlessioTiziana SquillaroIda LettieroGiovanni GalanoRoberto De RosaGianfranco PelusoUmberto GalderisiGiovanni Di BernardoMDPI AGarticlemesenchymal stem cellspolyphenolssenescencesenolyticsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11619, p 11619 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stem cells polyphenols senescence senolytics Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mesenchymal stem cells polyphenols senescence senolytics Biology (General) QH301-705.5 Chemistry QD1-999 Nicola Alessio Tiziana Squillaro Ida Lettiero Giovanni Galano Roberto De Rosa Gianfranco Peluso Umberto Galderisi Giovanni Di Bernardo Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
description	Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues. Using polyphenols in counteracting senescence may facilitate the development of senotherapeutics given their presence in the human diet, their confirmed tolerability and absence of severe side effects, and their role in preventing senescence and inducing the death of senescent cells. Against that background, we evaluated the effect of piceatannol, a natural polyphenol, on the senescence of mesenchymal stromal cells (MSCs), which play a key role in the body’s homeostasis. Among our results, piceatannol reduced the number of senescent cells both after genotoxic stress that induced acute senescence and in senescent replicative cultures. Such senotherapeutics activity, moreover, promoted the recovery of cell proliferation and the stemness properties of MSCs. Altogether, our findings demonstrate piceatannol’s effectiveness in counteracting senescence by targeting its associated pathways and detecting and affecting P53-dependent and P53-independent senescence. Our study thus suggests that, given piceatannol’s various mechanisms to accomplish its pleiotropic activities, it may be able to counteract any senescent phenotypes.
format	article
author	Nicola Alessio Tiziana Squillaro Ida Lettiero Giovanni Galano Roberto De Rosa Gianfranco Peluso Umberto Galderisi Giovanni Di Bernardo
author_facet	Nicola Alessio Tiziana Squillaro Ida Lettiero Giovanni Galano Roberto De Rosa Gianfranco Peluso Umberto Galderisi Giovanni Di Bernardo
author_sort	Nicola Alessio
title	Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_short	Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_full	Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_fullStr	Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_full_unstemmed	Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_sort	biomolecular evaluation of piceatannol’s effects in counteracting the senescence of mesenchymal stromal cells: a new candidate for senotherapeutics?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f6962f8ebda14c0f960a5395d7555367
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Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?

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